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Few cases of lymphomas, colorectal, prostate, stomach and pancreatic cancers displayed moderate cytoplasmic or nuclear positivity. Remaining cancer tissues were weakly stained or negative.
Few cases of gliomas, lymphomas, melanomas and urothelial cancers displayed moderate to strong nuclear staining. Few cases of colorectal cancers exhibited moderate positivity. Inflammatory cells were distinctly stained. Remaining cancer tissues were negative.
GENE INFORMATION
Gene name
SATB1
Synonyms
Description
SATB homeobox 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a matrix protein which binds nuclear matrix and scaffold-associating DNAs through a unique nuclear architecture. The protein recruits chromatin-remodeling factors in order to regulate chromatin structure and gene expression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
Q01826 [Direct mapping] DNA-binding protein SATB1 A0A024R2H1 [Target identity:100%; Query identity:100%] DNA-binding protein SATB
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Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0003677 [DNA binding] GO:0003690 [double-stranded DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0006915 [apoptotic process] GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] GO:0012501 [programmed cell death] GO:0016032 [viral process] GO:0016363 [nuclear matrix] GO:0016605 [PML body]
Q01826 [Direct mapping] DNA-binding protein SATB1 A0A024R2H1 [Target identity:100%; Query identity:100%] DNA-binding protein SATB
Show all
Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0003677 [DNA binding] GO:0003690 [double-stranded DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0006915 [apoptotic process] GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] GO:0012501 [programmed cell death] GO:0016032 [viral process] GO:0016363 [nuclear matrix] GO:0016605 [PML body]
Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000785 [chromatin] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003690 [double-stranded DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005720 [nuclear heterochromatin] GO:0006325 [chromatin organization] GO:0006338 [chromatin remodeling] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006915 [apoptotic process] GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] GO:0008544 [epidermis development] GO:0012501 [programmed cell death] GO:0016032 [viral process] GO:0016363 [nuclear matrix] GO:0016571 [histone methylation] GO:0016605 [PML body] GO:0042110 [T cell activation] GO:0043367 [CD4-positive, alpha-beta T cell differentiation] GO:0043374 [CD8-positive, alpha-beta T cell differentiation] GO:0050798 [activated T cell proliferation] GO:0060004 [reflex]
