We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Most cancers exhibited moderate membranous positivity. Few colorectal and endometrial cancers along with rare breast, stomach and thyroid cancers showed strong positivity. Gliomas, lymphomas, liver and renal cancers were negative.
GENE INFORMATION
Gene name
EPHB3 (HGNC Symbol)
Synonyms
ETK2, Hek2, Tyro6
Description
EPH receptor B3 (HGNC Symbol)
Entrez gene summary
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into two groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. This gene encodes a receptor for ephrin-B family members. [provided by RefSeq, Mar 2010]