Cell atlas - KCNB2 - The Human Protein Atlas

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KCNB2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS CELL CYCLE

GENE/PROTEIN

Antibody validation

Dictionary
	Midbody
	Nucleoli
	Plasma membrane

Human cell
	Microtubules
	Nucleoli
	Plasma Membrane

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GENERAL INFORMATION
Gene name	KCNB2
Gene description	Potassium channel, voltage gated Shab related subfamily B, member 2
Protein class	FDA approved drug targets Predicted membrane proteins Voltage-gated ion channels
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the plasma membrane. In addition localized to the nucleoli & midbody.
RNA cell category	Cell line enhanced (SCLC-21H, HEK 293, HDLM-2, HaCaT)
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (approved)
Additional location	In addition localized to the Nucleoli (approved), Midbody (approved)
Single-cell variation	Single-cell variation in protein expression observed.
Cell cycle dependency	Cell cycle dependent expression determined by biological definition

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA065970
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SCLC-21H, HEK 293, HDLM-2, HaCaT) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the plasma membrane. In addition localized to the nucleoli & midbody.

Main location

Plasma membrane (approved)

Additional location

Nucleoli (approved), Midbody (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA065970	HEK 293	Nucleoli
			Plasma membrane
			Midbody	Intensity	Intensity
	HPA065970	HaCaT	Nucleoli
			Plasma membrane
			Centrosome
	HPA065970	U-2 OS	Nucleoli
			Plasma membrane
			Midbody	Intensity	Intensity

CELL CYCLE
Summary	Expression has cell cycle dependency according to biological definition

GENE INFORMATION
Gene name	KCNB2 (HGNC Symbol)
Synonyms	Kv2.2
Description	Potassium channel, voltage gated Shab related subfamily B, member 2 (HGNC Symbol)
Entrez gene summary	Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel. The gene is expressed in gastrointestinal smooth muscle cells. [provided by RefSeq, Jul 2008]
Chromosome	8
Cytoband	q21.11
Chromosome location (bp)	72537391 - 72938349
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000182674 (version 83.38)
Entrez gene	9312
UniProt	Q92953 (UniProt - Evidence at transcript level)
neXtProt	NX_Q92953
Antibodypedia	KCNB2 antibodies

PROTEIN BROWSER

KCNB2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCNB2-001 ENSP00000430846 ENST00000523207	Q92953 [Direct mapping] Potassium voltage-gated channel subfamily B member 2 Show all	Voltage-gated ion channels Voltage-Gated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005249 [voltage-gated potassium channel activity] GO:0005251 [delayed rectifier potassium channel activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0006813 [potassium ion transport] GO:0006940 [regulation of smooth muscle contraction] GO:0007268 [synaptic transmission] GO:0008076 [voltage-gated potassium channel complex] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030425 [dendrite] GO:0032809 [neuronal cell body membrane] GO:0034765 [regulation of ion transmembrane transport] GO:0043204 [perikaryon] GO:0046982 [protein heterodimerization activity] GO:0051260 [protein homooligomerization] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] GO:0072661 [protein targeting to plasma membrane] Show all	911 aa 102.6 kDa	No	6

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.