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Cancer cells were in general weakly stained or negative. Renal cancers and a few hepatocellular carcinomas showed moderate to strong cytoplasmic immunoreactivity.
Several cases of liver cancers displayed strong cytoplasmic staining. Moderate staining was observed in a majority of cases of testicular, urothelial, renal, stomach, pancreatic and colorectal cancers. Remaining cancers were in general weakly stained or negative.
Hepatocellular carcinomas showed moderate to strong cytoplasmic and nuclear staining. Several cases of renal cancers displayed moderate to strong cytoplasmic, membranous and nuclear positivity. A few pancreatic cancers showed strong cytoplasmic and membranous immunoreactivity. Remaining cancers were generally negative.
GENE INFORMATION
Gene name
GSTA5
Synonyms
Description
Glutathione S-transferase alpha 5 (HGNC Symbol)
Entrez gene summary
The glutathione S-transferases (GST; EC 2.5.1.18) catalyze the conjugation of reduced glutathiones and a variety of electrophiles, including many known carcinogens and mutagens. The cytosolic GSTs belong to a large superfamily, with members located on different chromosomes. For additional information on GSTs, see GSTA1 (MIM 138359).[supplied by OMIM, Sep 2008]
