Cell atlas - CRIP2 - The Human Protein Atlas

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CRIP2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli
	Nucleus
	Plasma membrane

Human cell
	Nucleoli
	Nucleoplasm
	Plasma Membrane

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GENERAL INFORMATION
Gene name	CRIP2
Gene description	Cysteine-rich protein 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoli. In addition localized to the nucleus & plasma membrane.
RNA cell category	Cell line enhanced (MCF7)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli (approved)
Additional location	In addition localized to the Nucleus (approved), Plasma membrane (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA042664
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (MCF7) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoli. In addition localized to the nucleus & plasma membrane.

Main location

Nucleoli (approved)

Additional location

Nucleus (approved), Plasma membrane (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA042664	A-431	Nucleoli
	HPA042664	U-2 OS	Nucleus
			Nucleoli
			Plasma membrane
	HPA042664	U-251 MG	Nucleoli
	HPA042664	U-251 MG	Plasma membrane

GENE INFORMATION
Gene name	CRIP2 (HGNC Symbol)
Synonyms	CRP2, ESP1
Description	Cysteine-rich protein 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a putative transcription factor with two LIM zinc-binding domains. The encoded protein may participate in the differentiation of smooth muscle tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Chromosome	14
Cytoband	q32.33
Chromosome location (bp)	105472962 - 105480170
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000182809 (version 83.38)
Entrez gene	1397
UniProt	P52943 (UniProt - Evidence at protein level)
neXtProt	NX_P52943
Antibodypedia	CRIP2 antibodies

PROTEIN BROWSER

CRIP2-001	CRIP2-002	CRIP2-008	CRIP2-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CRIP2-001 ENSP00000328521 ENST00000329146	P52943 [Direct mapping] Cysteine-rich protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0008270 [zinc ion binding] GO:0031012 [extracellular matrix] Show all	208 aa 22.5 kDa	No	0
CRIP2-002 ENSP00000426119 ENST00000483017	P52943 [Direct mapping] Cysteine-rich protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005938 [cell cortex] GO:0008270 [zinc ion binding] GO:0008284 [positive regulation of cell proliferation] GO:0030097 [hemopoiesis] GO:0031012 [extracellular matrix] Show all	282 aa 30.2 kDa	No	0
CRIP2-008 ENSP00000446875 ENST00000550577	H0YHD8 [Direct mapping] Cysteine-rich protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008270 [zinc ion binding] Show all	104 aa 11 kDa	No	0
CRIP2-009 ENSP00000437723 ENST00000538259	H0YFA4 [Direct mapping] Cysteine-rich protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008270 [zinc ion binding] Show all	192 aa 20.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.