Expression of DDX28 in cancer - Summary

CANCER ATLAS

Gene description

DEAD (Asp-Glu-Ala-Asp) box polypeptide 28

Protein class

Enzymes, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA041911

GENE INFORMATION
Gene name	DDX28 (HGNC Symbol)
Synonyms	FLJ11282, MDDX28
Description	DEAD (Asp-Glu-Ala-Asp) box polypeptide 28 (HGNC Symbol)
Entrez gene summary	DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene is intronless. It encodes an RNA-dependent ATPase. The encoded protein is localized in the mitochondria and the nucleus, and can be transported between the mitochondria and the nucleus. [provided by RefSeq, Jul 2008]
Chromosome	16
Cytoband	q22.1
Chromosome location (bp)	68021274 - 68023442
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000182810 (version 83.38)
Entrez gene	55794
UniProt	Q9NUL7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NUL7
Antibodypedia	DDX28 antibodies

PROTEIN BROWSER

DDX28-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DDX28-001 ENSP00000332340 ENST00000332395	Q9NUL7 [Direct mapping] Probable ATP-dependent RNA helicase DDX28 Show all	Enzymes ENZYME proteins Hydrolases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0004004 [ATP-dependent RNA helicase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0010501 [RNA secondary structure unwinding] GO:0019843 [rRNA binding] GO:0035770 [ribonucleoprotein granule] GO:0042645 [mitochondrial nucleoid] GO:0044822 [poly(A) RNA binding] GO:1902775 [mitochondrial large ribosomal subunit assembly] Show all	540 aa 59.6 kDa	Yes	0