Expression of EWSR1 in cancer - Summary

CANCER ATLAS

Gene description

EWS RNA-binding protein 1

Protein class

Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA051771	HPA062953	CAB004230

GENE INFORMATION
Gene name	EWSR1 (HGNC Symbol)
Synonyms	EWS
Description	EWS RNA-binding protein 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14. [provided by RefSeq, Jul 2009]
Chromosome	22
Cytoband	q12.2
Chromosome location (bp)	29268009 - 29300525
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000182944 (version 83.38)
Entrez gene	2130
UniProt	Q01844 (UniProt - Evidence at protein level)
neXtProt	NX_Q01844
Antibodypedia	EWSR1 antibodies

PROTEIN BROWSER

EWSR1-001	EWSR1-002	EWSR1-004	EWSR1-007	EWSR1-008	EWSR1-012	EWSR1-013	EWSR1-014	EWSR1-016	EWSR1-017	EWSR1-018	EWSR1-019	EWSR1-021	EWSR1-201	EWSR1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EWSR1-001 ENSP00000381031 ENST00000397938	Q01844 [Direct mapping] RNA-binding protein EWS Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0042802 [identical protein binding] GO:0044822 [poly(A) RNA binding] Show all	656 aa 68.5 kDa	No	0
EWSR1-002 ENSP00000385726 ENST00000406548	Q01844 [Direct mapping] RNA-binding protein EWS Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0042802 [identical protein binding] GO:0044822 [poly(A) RNA binding] Show all	655 aa 68.4 kDa	No	0
EWSR1-004 ENSP00000327456 ENST00000333395	Q01844 [Direct mapping] RNA-binding protein EWS Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0042802 [identical protein binding] GO:0044822 [poly(A) RNA binding] Show all	354 aa 37.6 kDa	No	0
EWSR1-007 ENSP00000330516 ENST00000331029	B0QYK0 [Direct mapping] RNA-binding protein EWS Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0008270 [zinc ion binding] Show all	618 aa 64.9 kDa	No	0
EWSR1-008 ENSP00000331699 ENST00000332035	Q01844 [Direct mapping] RNA-binding protein EWS Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0042802 [identical protein binding] GO:0044822 [poly(A) RNA binding] Show all	600 aa 62.5 kDa	No	0
EWSR1-012 ENSP00000406824 ENST00000436425	B0QYJ3 [Direct mapping] RNA-binding protein EWS Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		156 aa 16.3 kDa	No	0
EWSR1-013 ENSP00000412670 ENST00000437155	F8WC90 [Direct mapping] RNA-binding protein EWS Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		293 aa 31.1 kDa	No	0
EWSR1-014 ENSP00000405947 ENST00000447973	B0QYJ4 [Direct mapping] RNA-binding protein EWS Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		166 aa 17.3 kDa	No	0
EWSR1-016 ENSP00000416171 ENST00000444626	B0QYJ5 [Direct mapping] RNA-binding protein EWS Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		77 aa 8.2 kDa	No	0
EWSR1-017 ENSP00000395200 ENST00000415761	B0QYJ6 [Direct mapping] RNA-binding protein EWS Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		180 aa 19.2 kDa	No	0
EWSR1-018 ENSP00000393637 ENST00000455726	B0QYJ7 [Direct mapping] RNA-binding protein EWS Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		233 aa 24.6 kDa	No	0
EWSR1-019 ENSP00000353204 ENST00000360091	H7BY36 [Direct mapping] RNA-binding protein EWS Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0008270 [zinc ion binding] Show all	308 aa 32.1 kDa	No	0
EWSR1-021 ENSP00000400142 ENST00000414183	Q01844 [Direct mapping] RNA-binding protein EWS Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0042802 [identical protein binding] GO:0044822 [poly(A) RNA binding] Show all	661 aa 69 kDa	No	0
EWSR1-201 ENSP00000330896 ENST00000332050	C9JGE3 [Direct mapping] EWS RNA-binding protein variant 6; RNA-binding protein EWS Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0008270 [zinc ion binding] Show all	620 aa 65.1 kDa	No	0
EWSR1-202 ENSP00000486709 ENST00000629659	A0A0D9SFL3 [Direct mapping] RNA-binding protein EWS Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0008270 [zinc ion binding] Show all	584 aa 61.4 kDa	No	0