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AP2A2

CANCER ATLAS

Gene description

 Adaptor-related protein complex 2, alpha 2 subunit

Protein class

 Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB017514

GENE INFORMATION

Gene name

 AP2A2 (HGNC Symbol)

Synonyms

 ADTAB, CLAPA2, DKFZP564D1864, HIP9, HYPJ, KIAA0899

Description

 Adaptor-related protein complex 2, alpha 2 subunit (HGNC Symbol)

Entrez gene summary

Chromosome

 11

Cytoband

 p15.5

Chromosome location (bp)

 924894 - 1012245

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000183020 (version 83.38)

Entrez gene

 161

UniProt

 O94973 (UniProt - Evidence at protein level)

neXtProt

 NX_O94973

Antibodypedia

 AP2A2 antibodies

PROTEIN BROWSER
AP2A2-001
AP2A2-004
AP2A2-016
AP2A2-017
AP2A2-018
AP2A2-019
AP2A2-020
AP2A2-022
AP2A2-023
AP2A2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AP2A2-001
ENSP00000413234
ENST00000448903
O94973 [Direct mapping]
AP-2 complex subunit alpha-2
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003674 [molecular_function]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0008289 [lipid binding]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016032 [viral process]
GO:0016192 [vesicle-mediated transport]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0019901 [protein kinase binding]
GO:0030117 [membrane coat]
GO:0030122 [AP-2 adaptor complex]
GO:0030131 [clathrin adaptor complex]
GO:0030666 [endocytic vesicle membrane]
GO:0030669 [clathrin-coated endocytic vesicle membrane]
GO:0035615 [clathrin adaptor activity]
GO:0036020 [endolysosome membrane]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0050690 [regulation of defense response to virus by virus]
GO:0072583 [clathrin-mediated endocytosis]
Show all
 939 aa
104 kDa 		No 0
AP2A2-004
ENSP00000436059
ENST00000534328
E9PR62 [Direct mapping]
AP-2 complex subunit alpha-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0006886 [intracellular protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030117 [membrane coat]
Show all
 378 aa
42 kDa 		No 0
AP2A2-016
ENSP00000435863
ENST00000526753
E9PS94 [Direct mapping]
AP-2 complex subunit alpha-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0006886 [intracellular protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030117 [membrane coat]
Show all
 62 aa
6.9 kDa 		No 0
AP2A2-017
ENSP00000433498
ENST00000531548
H0YDE9 [Direct mapping]
AP-2 complex subunit alpha-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0006886 [intracellular protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030117 [membrane coat]
Show all
 185 aa
20.5 kDa 		No 0
AP2A2-018
ENSP00000435756
ENST00000534485
H0YEG0 [Direct mapping]
AP-2 complex subunit alpha-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0006886 [intracellular protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030117 [membrane coat]
Show all
 185 aa
20.8 kDa 		No 0
AP2A2-019
ENSP00000434432
ENST00000524559
E9PQP4 [Direct mapping]
AP-2 complex subunit alpha-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0006886 [intracellular protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030117 [membrane coat]
Show all
 90 aa
9.8 kDa 		No 0
AP2A2-020
ENSP00000434563
ENST00000527024
E9PPY8 [Direct mapping]
AP-2 complex subunit alpha-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0006886 [intracellular protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030117 [membrane coat]
Show all
 138 aa
15.6 kDa 		No 0
AP2A2-022
ENSP00000434553
ENST00000530801
E9PPZ3 [Direct mapping]
AP-2 complex subunit alpha-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0006886 [intracellular protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030117 [membrane coat]
Show all
 60 aa
6.7 kDa 		No 0
AP2A2-023
ENSP00000437228
ENST00000525796
E9PNC4 [Direct mapping]
AP-2 complex subunit alpha-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0006886 [intracellular protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030117 [membrane coat]
Show all
 125 aa
13.9 kDa 		No 0
AP2A2-201
ENSP00000327694
ENST00000332231
O94973 [Direct mapping]
AP-2 complex subunit alpha-2
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003674 [molecular_function]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0008289 [lipid binding]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016032 [viral process]
GO:0016192 [vesicle-mediated transport]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0019901 [protein kinase binding]
GO:0030117 [membrane coat]
GO:0030122 [AP-2 adaptor complex]
GO:0030131 [clathrin adaptor complex]
GO:0030666 [endocytic vesicle membrane]
GO:0030669 [clathrin-coated endocytic vesicle membrane]
GO:0032403 [protein complex binding]
GO:0035615 [clathrin adaptor activity]
GO:0036020 [endolysosome membrane]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0050690 [regulation of defense response to virus by virus]
GO:0072583 [clathrin-mediated endocytosis]
Show all
 940 aa
104.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.