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SLC8A1

GENERAL INFORMATION

Gene name

 SLC8A1

Gene description

 Solute carrier family 8 (sodium/calcium exchanger), member 1

Protein class

 FDA approved drug targets
Predicted membrane proteins
Predicted secreted proteins
Transporters

Predicted localization

 Membrane,Secreted

Number of transcripts

 11
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (heart muscle)
GTEx:Tissue enhanced (heart muscle)
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression, in some tissues with a granular pattern.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
CAB022694
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Thyroid gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (heart muscle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (heart muscle)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 SLC8A1 (HGNC Symbol)

Synonyms

 NCX1

Description

 Solute carrier family 8 (sodium/calcium exchanger), member 1 (HGNC Symbol)

Entrez gene summary

 In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.[supplied by OMIM, Apr 2004]

Chromosome

 2

Cytoband

 p22.1

Chromosome location (bp)

 40097270 - 40611053

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000183023 (version 83.38)

Entrez gene

 6546

UniProt

 P32418 (UniProt - Evidence at protein level)

neXtProt

 NX_P32418

Antibodypedia

 SLC8A1 antibodies

PROTEIN BROWSER
«
SLC8A1-003
SLC8A1-004
SLC8A1-005
SLC8A1-006
SLC8A1-008
SLC8A1-009
SLC8A1-010
SLC8A1-012
SLC8A1-013
SLC8A1-201
SLC8A1-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC8A1-003
ENSP00000385678
ENST00000405901
P32418 [Direct mapping]
Sodium/calcium exchanger 1
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002026 [regulation of the force of heart contraction]
GO:0002027 [regulation of heart rate]
GO:0005432 [calcium:sodium antiporter activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0006883 [cellular sodium ion homeostasis]
GO:0006936 [muscle contraction]
GO:0007154 [cell communication]
GO:0007596 [blood coagulation]
GO:0008092 [cytoskeletal protein binding]
GO:0010649 [regulation of cell communication by electrical coupling]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0010882 [regulation of cardiac muscle contraction by calcium ion signaling]
GO:0014704 [intercalated disc]
GO:0014829 [vascular smooth muscle contraction]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030018 [Z disc]
GO:0030315 [T-tubule]
GO:0030501 [positive regulation of bone mineralization]
GO:0030506 [ankyrin binding]
GO:0034614 [cellular response to reactive oxygen species]
GO:0035725 [sodium ion transmembrane transport]
GO:0035994 [response to muscle stretch]
GO:0042383 [sarcolemma]
GO:0044325 [ion channel binding]
GO:0044557 [relaxation of smooth muscle]
GO:0051481 [negative regulation of cytosolic calcium ion concentration]
GO:0055013 [cardiac muscle cell development]
GO:0055074 [calcium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:0055119 [relaxation of cardiac muscle]
GO:0060048 [cardiac muscle contraction]
GO:0060401 [cytosolic calcium ion transport]
GO:0060402 [calcium ion transport into cytosol]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0071313 [cellular response to caffeine]
GO:0071436 [sodium ion export]
GO:0086012 [membrane depolarization during cardiac muscle cell action potential]
GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]
GO:0097369 [sodium ion import]
GO:0098735 [positive regulation of the force of heart contraction]
GO:1901660 [calcium ion export]
Show all
 968 aa
107.9 kDa 		Yes >9
SLC8A1-004
ENSP00000389330
ENST00000455476
E9PCL8 [Direct mapping]
Sodium/calcium exchanger 1
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005432 [calcium:sodium antiporter activity]
GO:0006816 [calcium ion transport]
GO:0016020 [membrane]
GO:0035725 [sodium ion transmembrane transport]
Show all
 87 aa
9.8 kDa 		Yes 0
SLC8A1-005
ENSP00000383886
ENST00000406785
P32418 [Direct mapping]
Sodium/calcium exchanger 1
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002026 [regulation of the force of heart contraction]
GO:0002027 [regulation of heart rate]
GO:0005432 [calcium:sodium antiporter activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0006883 [cellular sodium ion homeostasis]
GO:0006936 [muscle contraction]
GO:0007154 [cell communication]
GO:0007596 [blood coagulation]
GO:0008092 [cytoskeletal protein binding]
GO:0010649 [regulation of cell communication by electrical coupling]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0010882 [regulation of cardiac muscle contraction by calcium ion signaling]
GO:0014704 [intercalated disc]
GO:0014829 [vascular smooth muscle contraction]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030018 [Z disc]
GO:0030315 [T-tubule]
GO:0030501 [positive regulation of bone mineralization]
GO:0030506 [ankyrin binding]
GO:0034614 [cellular response to reactive oxygen species]
GO:0035725 [sodium ion transmembrane transport]
GO:0035994 [response to muscle stretch]
GO:0042383 [sarcolemma]
GO:0044325 [ion channel binding]
GO:0044557 [relaxation of smooth muscle]
GO:0051481 [negative regulation of cytosolic calcium ion concentration]
GO:0055013 [cardiac muscle cell development]
GO:0055074 [calcium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:0055119 [relaxation of cardiac muscle]
GO:0060048 [cardiac muscle contraction]
GO:0060401 [cytosolic calcium ion transport]
GO:0060402 [calcium ion transport into cytosol]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0071313 [cellular response to caffeine]
GO:0071436 [sodium ion export]
GO:0086012 [membrane depolarization during cardiac muscle cell action potential]
GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]
GO:0097369 [sodium ion import]
GO:0098735 [positive regulation of the force of heart contraction]
GO:1901660 [calcium ion export]
Show all
 937 aa
104.7 kDa 		Yes >9
SLC8A1-006
ENSP00000385188
ENST00000402441
P32418 [Direct mapping]
Sodium/calcium exchanger 1
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002026 [regulation of the force of heart contraction]
GO:0002027 [regulation of heart rate]
GO:0005432 [calcium:sodium antiporter activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0006883 [cellular sodium ion homeostasis]
GO:0006936 [muscle contraction]
GO:0007154 [cell communication]
GO:0007596 [blood coagulation]
GO:0008092 [cytoskeletal protein binding]
GO:0010649 [regulation of cell communication by electrical coupling]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0010882 [regulation of cardiac muscle contraction by calcium ion signaling]
GO:0014704 [intercalated disc]
GO:0014829 [vascular smooth muscle contraction]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030018 [Z disc]
GO:0030315 [T-tubule]
GO:0030501 [positive regulation of bone mineralization]
GO:0030506 [ankyrin binding]
GO:0034614 [cellular response to reactive oxygen species]
GO:0035725 [sodium ion transmembrane transport]
GO:0035994 [response to muscle stretch]
GO:0042383 [sarcolemma]
GO:0044325 [ion channel binding]
GO:0044557 [relaxation of smooth muscle]
GO:0051481 [negative regulation of cytosolic calcium ion concentration]
GO:0055013 [cardiac muscle cell development]
GO:0055074 [calcium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:0055119 [relaxation of cardiac muscle]
GO:0060048 [cardiac muscle contraction]
GO:0060401 [cytosolic calcium ion transport]
GO:0060402 [calcium ion transport into cytosol]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0071313 [cellular response to caffeine]
GO:0071436 [sodium ion export]
GO:0086012 [membrane depolarization during cardiac muscle cell action potential]
GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]
GO:0097369 [sodium ion import]
GO:0098735 [positive regulation of the force of heart contraction]
GO:1901660 [calcium ion export]
Show all
 937 aa
104.7 kDa 		Yes >9
SLC8A1-008
ENSP00000398575
ENST00000448531
E9PCL8 [Direct mapping]
Sodium/calcium exchanger 1
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005432 [calcium:sodium antiporter activity]
GO:0006816 [calcium ion transport]
GO:0016020 [membrane]
GO:0035725 [sodium ion transmembrane transport]
Show all
 87 aa
9.8 kDa 		Yes 0
SLC8A1-009
ENSP00000412560
ENST00000417271
E9PB98 [Direct mapping]
Sodium/calcium exchanger 1
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005432 [calcium:sodium antiporter activity]
GO:0006816 [calcium ion transport]
GO:0016020 [membrane]
GO:0035725 [sodium ion transmembrane transport]
Show all
 73 aa
8.2 kDa 		Yes 0
SLC8A1-010
ENSP00000384763
ENST00000403092
P32418 [Direct mapping]
Sodium/calcium exchanger 1
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   9TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0001892 [embryonic placenta development]
GO:0002026 [regulation of the force of heart contraction]
GO:0002027 [regulation of heart rate]
GO:0002028 [regulation of sodium ion transport]
GO:0003007 [heart morphogenesis]
GO:0005432 [calcium:sodium antiporter activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006814 [sodium ion transport]
GO:0006816 [calcium ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0006883 [cellular sodium ion homeostasis]
GO:0006936 [muscle contraction]
GO:0007154 [cell communication]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007584 [response to nutrient]
GO:0007596 [blood coagulation]
GO:0008092 [cytoskeletal protein binding]
GO:0009749 [response to glucose]
GO:0009791 [post-embryonic development]
GO:0010649 [regulation of cell communication by electrical coupling]
GO:0010763 [positive regulation of fibroblast migration]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0010882 [regulation of cardiac muscle contraction by calcium ion signaling]
GO:0014704 [intercalated disc]
GO:0014829 [vascular smooth muscle contraction]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0021537 [telencephalon development]
GO:0030018 [Z disc]
GO:0030315 [T-tubule]
GO:0030501 [positive regulation of bone mineralization]
GO:0030506 [ankyrin binding]
GO:0033198 [response to ATP]
GO:0034614 [cellular response to reactive oxygen species]
GO:0035050 [embryonic heart tube development]
GO:0035725 [sodium ion transmembrane transport]
GO:0035902 [response to immobilization stress]
GO:0035994 [response to muscle stretch]
GO:0042383 [sarcolemma]
GO:0042493 [response to drug]
GO:0042542 [response to hydrogen peroxide]
GO:0042995 [cell projection]
GO:0043197 [dendritic spine]
GO:0043198 [dendritic shaft]
GO:0044325 [ion channel binding]
GO:0044557 [relaxation of smooth muscle]
GO:0048747 [muscle fiber development]
GO:0051481 [negative regulation of cytosolic calcium ion concentration]
GO:0051924 [regulation of calcium ion transport]
GO:0055013 [cardiac muscle cell development]
GO:0055074 [calcium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:0055119 [relaxation of cardiac muscle]
GO:0060048 [cardiac muscle contraction]
GO:0060401 [cytosolic calcium ion transport]
GO:0060402 [calcium ion transport into cytosol]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0071313 [cellular response to caffeine]
GO:0071320 [cellular response to cAMP]
GO:0071436 [sodium ion export]
GO:0071456 [cellular response to hypoxia]
GO:0086012 [membrane depolarization during cardiac muscle cell action potential]
GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]
GO:0097369 [sodium ion import]
GO:0098735 [positive regulation of the force of heart contraction]
GO:1901660 [calcium ion export]
Show all
 973 aa
108.5 kDa 		Yes 9
SLC8A1-012
ENSP00000385535
ENST00000405269
P32418 [Direct mapping]
Sodium/calcium exchanger 1
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002026 [regulation of the force of heart contraction]
GO:0002027 [regulation of heart rate]
GO:0005432 [calcium:sodium antiporter activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0006883 [cellular sodium ion homeostasis]
GO:0006936 [muscle contraction]
GO:0007154 [cell communication]
GO:0007596 [blood coagulation]
GO:0008092 [cytoskeletal protein binding]
GO:0010649 [regulation of cell communication by electrical coupling]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0010882 [regulation of cardiac muscle contraction by calcium ion signaling]
GO:0014704 [intercalated disc]
GO:0014829 [vascular smooth muscle contraction]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030018 [Z disc]
GO:0030315 [T-tubule]
GO:0030501 [positive regulation of bone mineralization]
GO:0030506 [ankyrin binding]
GO:0034614 [cellular response to reactive oxygen species]
GO:0035725 [sodium ion transmembrane transport]
GO:0035994 [response to muscle stretch]
GO:0042383 [sarcolemma]
GO:0044325 [ion channel binding]
GO:0044557 [relaxation of smooth muscle]
GO:0051481 [negative regulation of cytosolic calcium ion concentration]
GO:0055013 [cardiac muscle cell development]
GO:0055074 [calcium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:0055119 [relaxation of cardiac muscle]
GO:0060048 [cardiac muscle contraction]
GO:0060401 [cytosolic calcium ion transport]
GO:0060402 [calcium ion transport into cytosol]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0071313 [cellular response to caffeine]
GO:0071436 [sodium ion export]
GO:0086012 [membrane depolarization during cardiac muscle cell action potential]
GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]
GO:0097369 [sodium ion import]
GO:0098735 [positive regulation of the force of heart contraction]
GO:1901660 [calcium ion export]
Show all
 937 aa
104.7 kDa 		Yes >9
SLC8A1-013
ENSP00000384908
ENST00000408028
P32418 [Direct mapping]
Sodium/calcium exchanger 1
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002026 [regulation of the force of heart contraction]
GO:0002027 [regulation of heart rate]
GO:0005432 [calcium:sodium antiporter activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0006883 [cellular sodium ion homeostasis]
GO:0006936 [muscle contraction]
GO:0007154 [cell communication]
GO:0007596 [blood coagulation]
GO:0008092 [cytoskeletal protein binding]
GO:0010649 [regulation of cell communication by electrical coupling]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0010882 [regulation of cardiac muscle contraction by calcium ion signaling]
GO:0014704 [intercalated disc]
GO:0014829 [vascular smooth muscle contraction]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030018 [Z disc]
GO:0030315 [T-tubule]
GO:0030501 [positive regulation of bone mineralization]
GO:0030506 [ankyrin binding]
GO:0034614 [cellular response to reactive oxygen species]
GO:0035725 [sodium ion transmembrane transport]
GO:0035994 [response to muscle stretch]
GO:0042383 [sarcolemma]
GO:0044325 [ion channel binding]
GO:0044557 [relaxation of smooth muscle]
GO:0051481 [negative regulation of cytosolic calcium ion concentration]
GO:0055013 [cardiac muscle cell development]
GO:0055074 [calcium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:0055119 [relaxation of cardiac muscle]
GO:0060048 [cardiac muscle contraction]
GO:0060401 [cytosolic calcium ion transport]
GO:0060402 [calcium ion transport into cytosol]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0071313 [cellular response to caffeine]
GO:0071436 [sodium ion export]
GO:0086012 [membrane depolarization during cardiac muscle cell action potential]
GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]
GO:0097369 [sodium ion import]
GO:0098735 [positive regulation of the force of heart contraction]
GO:1901660 [calcium ion export]
Show all
 965 aa
107.8 kDa 		Yes >9
SLC8A1-201
ENSP00000332931
ENST00000332839
P32418 [Direct mapping]
Sodium/calcium exchanger 1
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   9TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002026 [regulation of the force of heart contraction]
GO:0002027 [regulation of heart rate]
GO:0005432 [calcium:sodium antiporter activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0006883 [cellular sodium ion homeostasis]
GO:0006936 [muscle contraction]
GO:0007154 [cell communication]
GO:0007596 [blood coagulation]
GO:0008092 [cytoskeletal protein binding]
GO:0010649 [regulation of cell communication by electrical coupling]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0010882 [regulation of cardiac muscle contraction by calcium ion signaling]
GO:0014704 [intercalated disc]
GO:0014829 [vascular smooth muscle contraction]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030018 [Z disc]
GO:0030315 [T-tubule]
GO:0030501 [positive regulation of bone mineralization]
GO:0030506 [ankyrin binding]
GO:0034614 [cellular response to reactive oxygen species]
GO:0035725 [sodium ion transmembrane transport]
GO:0035994 [response to muscle stretch]
GO:0042383 [sarcolemma]
GO:0044325 [ion channel binding]
GO:0044557 [relaxation of smooth muscle]
GO:0051481 [negative regulation of cytosolic calcium ion concentration]
GO:0055013 [cardiac muscle cell development]
GO:0055074 [calcium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:0055119 [relaxation of cardiac muscle]
GO:0060048 [cardiac muscle contraction]
GO:0060401 [cytosolic calcium ion transport]
GO:0060402 [calcium ion transport into cytosol]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0071313 [cellular response to caffeine]
GO:0071436 [sodium ion export]
GO:0086012 [membrane depolarization during cardiac muscle cell action potential]
GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]
GO:0097369 [sodium ion import]
GO:0098735 [positive regulation of the force of heart contraction]
GO:1901660 [calcium ion export]
Show all
 973 aa
108.5 kDa 		Yes 9
SLC8A1-202
ENSP00000385811
ENST00000406391
P32418 [Direct mapping]
Sodium/calcium exchanger 1
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Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002026 [regulation of the force of heart contraction]
GO:0002027 [regulation of heart rate]
GO:0005432 [calcium:sodium antiporter activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0006883 [cellular sodium ion homeostasis]
GO:0006936 [muscle contraction]
GO:0007154 [cell communication]
GO:0007596 [blood coagulation]
GO:0008092 [cytoskeletal protein binding]
GO:0010649 [regulation of cell communication by electrical coupling]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0010882 [regulation of cardiac muscle contraction by calcium ion signaling]
GO:0014704 [intercalated disc]
GO:0014829 [vascular smooth muscle contraction]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030018 [Z disc]
GO:0030315 [T-tubule]
GO:0030501 [positive regulation of bone mineralization]
GO:0030506 [ankyrin binding]
GO:0034614 [cellular response to reactive oxygen species]
GO:0035725 [sodium ion transmembrane transport]
GO:0035994 [response to muscle stretch]
GO:0042383 [sarcolemma]
GO:0044325 [ion channel binding]
GO:0044557 [relaxation of smooth muscle]
GO:0051481 [negative regulation of cytosolic calcium ion concentration]
GO:0055013 [cardiac muscle cell development]
GO:0055074 [calcium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:0055119 [relaxation of cardiac muscle]
GO:0060048 [cardiac muscle contraction]
GO:0060401 [cytosolic calcium ion transport]
GO:0060402 [calcium ion transport into cytosol]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0071313 [cellular response to caffeine]
GO:0071436 [sodium ion export]
GO:0086012 [membrane depolarization during cardiac muscle cell action potential]
GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]
GO:0097369 [sodium ion import]
GO:0098735 [positive regulation of the force of heart contraction]
GO:1901660 [calcium ion export]
Show all
 937 aa
104.7 kDa 		Yes >9

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.