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Hepatocellular carcinomas, papillary adenocarcinomas of thyroid, malignant gliomas, several breast cancers along with a few cases of colorectal, urothelial and pancreatic cancers exhibited moderate to strong granular cytoplasmic positivity. Moderate staining was observed in prostate cancers. Remaining malignant cells were negative.
A majority of malignant cells exhibited moderate to strong granular cytoplasmic positivity. Most cases of malignant melanomas, endometrial cancers, testicular cancers, squamous and basal cell carcinomas were negative.
GENE INFORMATION
Gene name
ABAT (HGNC Symbol)
Synonyms
GABAT
Description
4-aminobutyrate aminotransferase (HGNC Symbol)
Entrez gene summary
4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]
Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001666 [response to hypoxia] GO:0003867 [4-aminobutyrate transaminase activity] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0007268 [synaptic transmission] GO:0007269 [neurotransmitter secretion] GO:0007568 [aging] GO:0007620 [copulation] GO:0007626 [locomotory behavior] GO:0008483 [transaminase activity] GO:0009448 [gamma-aminobutyric acid metabolic process] GO:0009449 [gamma-aminobutyric acid biosynthetic process] GO:0009450 [gamma-aminobutyric acid catabolic process] GO:0010039 [response to iron ion] GO:0014053 [negative regulation of gamma-aminobutyric acid secretion] GO:0021549 [cerebellum development] GO:0030170 [pyridoxal phosphate binding] GO:0031652 [positive regulation of heat generation] GO:0032024 [positive regulation of insulin secretion] GO:0032144 [4-aminobutyrate transaminase complex] GO:0032145 [succinate-semialdehyde dehydrogenase binding] GO:0033602 [negative regulation of dopamine secretion] GO:0035094 [response to nicotine] GO:0035640 [exploration behavior] GO:0042135 [neurotransmitter catabolic process] GO:0042220 [response to cocaine] GO:0042493 [response to drug] GO:0042803 [protein homodimerization activity] GO:0043005 [neuron projection] GO:0045471 [response to ethanol] GO:0045776 [negative regulation of blood pressure] GO:0045964 [positive regulation of dopamine metabolic process] GO:0046872 [metal ion binding] GO:0047298 [(S)-3-amino-2-methylpropionate transaminase activity] GO:0048148 [behavioral response to cocaine] GO:0051536 [iron-sulfur cluster binding] GO:0070062 [extracellular exosome] GO:0070474 [positive regulation of uterine smooth muscle contraction] GO:0090331 [negative regulation of platelet aggregation] GO:0097151 [positive regulation of inhibitory postsynaptic potential] GO:1902722 [positive regulation of prolactin secretion] GO:1904450 [positive regulation of aspartate secretion]
