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Cancer tissues showed moderate cytoplasmic immunoreactivity. In urothelial cancers, additional staining of nuclear membranes was observed.
GENE INFORMATION
Gene name
CAMK1D (HGNC Symbol)
Synonyms
CKLiK
Description
Calcium/calmodulin-dependent protein kinase ID (HGNC Symbol)
Entrez gene summary
This gene is a member of the calcium/calmodulin-dependent protein kinase 1 family, a subfamily of the serine/threonine kinases. The encoded protein is a component of the calcium-regulated calmodulin-dependent protein kinase cascade. It has been associated with multiple processes including regulation of granulocyte function, activation of CREB-dependent gene transcription, aldosterone synthesis, differentiation and activation of neutrophil cells, and apoptosis of erythroleukemia cells. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jan 2015]
Q8IU85 [Direct mapping] Calcium/calmodulin-dependent protein kinase type 1D Q5SQQ7 [Target identity:100%; Query identity:100%] Calcium/calmodulin-dependent protein kinase ID, isoform CRA_b; Calcium/calmodulin-dependent protein kinase type 1D variant 2; Calcium/calmodulin-dependent protein kinase type 1D variant 3; cDNA FLJ76987, highly similar to Homo sapiens calcium/calmodulin-dependent protein kinase ID (CAMK1D), transcript variant 1, mRNA
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Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0004672 [protein kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0006954 [inflammatory response] GO:0010976 [positive regulation of neuron projection development] GO:0032793 [positive regulation of CREB transcription factor activity] GO:0050766 [positive regulation of phagocytosis] GO:0050773 [regulation of dendrite development] GO:0060267 [positive regulation of respiratory burst] GO:0071622 [regulation of granulocyte chemotaxis] GO:0090023 [positive regulation of neutrophil chemotaxis]
