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DDX41

GENERAL INFORMATION

Gene name

 DDX41

Gene description

 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA017911 , HPA048803
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 DDX41 (HGNC Symbol)

Synonyms

 ABS, MGC8828

Description

 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 (HGNC Symbol)

Entrez gene summary

 DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Based on studies in Drosophila, the abstrakt gene is widely required during post-transcriptional gene expression. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 q35.3

Chromosome location (bp)

 177511577 - 177517469

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000183258 (version 83.38)

Entrez gene

 51428

UniProt

 Q9UJV9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UJV9

Antibodypedia

 DDX41 antibodies

PROTEIN BROWSER
DDX41-001
DDX41-004
DDX41-201
DDX41-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DDX41-001
ENSP00000422753
ENST00000507955
Q9UJV9 [Direct mapping]
Probable ATP-dependent RNA helicase DDX41
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006396 [RNA processing]
GO:0006915 [apoptotic process]
GO:0007275 [multicellular organismal development]
GO:0008270 [zinc ion binding]
GO:0010501 [RNA secondary structure unwinding]
GO:0016020 [membrane]
GO:0032479 [regulation of type I interferon production]
GO:0032481 [positive regulation of type I interferon production]
GO:0035458 [cellular response to interferon-beta]
GO:0044822 [poly(A) RNA binding]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051607 [defense response to virus]
GO:0071013 [catalytic step 2 spliceosome]
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 622 aa
69.8 kDa 		No 0
DDX41-004
ENSP00000330349
ENST00000330503
J3KNN5 [Direct mapping]
Probable ATP-dependent RNA helicase DDX41
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0005524 [ATP binding]
GO:0008270 [zinc ion binding]
GO:0010501 [RNA secondary structure unwinding]
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 640 aa
71.6 kDa 		No 0
DDX41-201
ENSP00000487280
ENST00000625286
D6RD33 [Direct mapping]
Probable ATP-dependent RNA helicase DDX41
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0010501 [RNA secondary structure unwinding]
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 49 aa
5.6 kDa 		No 0
DDX41-202
ENSP00000486367
ENST00000629036
D6RGI7 [Direct mapping]
Probable ATP-dependent RNA helicase DDX41
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0010501 [RNA secondary structure unwinding]
Show all
 201 aa
23 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.