Expression of FBXL7 in cancer - Summary

CANCER ATLAS

Gene description

F-box and leucine-rich repeat protein 7

Protein class

Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA055464

GENE INFORMATION
Gene name	FBXL7 (HGNC Symbol)
Synonyms	FBL6, FBL7, KIAA0840
Description	F-box and leucine-rich repeat protein 7 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the F-box protein family which is characterized by a 42-48 amino acid motif, the F-box, which binds to the S-phase kinase-associated protein 1 (Skp1) protein. The F-box proteins constitute one of the four subunits of E3 ubiquitin protein ligases called SCFs (SKP1-Cul1-F-box), which play a role in phosphorylation-dependent ubiquitination of proteins. The F-box proteins are divided into 3 subfamilies based on the other domain in the protein: F-box proteins that also have a WD-40 domain (Fbws subfamily), F-box proteins that also have leucine-rich repeats (Fbls subfamily) and F-box proteins that contain other motifs or lack known protein-interaction domains (Fbxs subfamily). The protein encoded by this gene belongs to the Fbls subfamily. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
Chromosome	5
Cytoband	p15.1
Chromosome location (bp)	15500196 - 15939795
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183580 (version 83.38)
Entrez gene	23194
UniProt	Q9UJT9 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9UJT9
Antibodypedia	FBXL7 antibodies

PROTEIN BROWSER

FBXL7-001	FBXL7-002	FBXL7-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FBXL7-001 ENSP00000423630 ENST00000504595	Q9UJT9 [Direct mapping] F-box/LRR-repeat protein 7 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000151 [ubiquitin ligase complex] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0007067 [mitotic nuclear division] GO:0008283 [cell proliferation] GO:0016567 [protein ubiquitination] GO:0019005 [SCF ubiquitin ligase complex] GO:0031146 [SCF-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0051301 [cell division] GO:0061630 [ubiquitin protein ligase activity] Show all	491 aa 54.6 kDa	No	0
FBXL7-002 ENSP00000425184 ENST00000510662	Q9UJT9 [Direct mapping] F-box/LRR-repeat protein 7 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000151 [ubiquitin ligase complex] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0007067 [mitotic nuclear division] GO:0008283 [cell proliferation] GO:0016567 [protein ubiquitination] GO:0019005 [SCF ubiquitin ligase complex] GO:0031146 [SCF-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0051301 [cell division] GO:0061630 [ubiquitin protein ligase activity] Show all	444 aa 49.8 kDa	No	0
FBXL7-201 ENSP00000329632 ENST00000329673	J3KNM9 [Direct mapping] F-box/LRR-repeat protein 7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	449 aa 50.4 kDa	No	0