Cell atlas - SFXN4 - The Human Protein Atlas

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SFXN4

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Vesicles

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	SFXN4
Gene description	Sideroflexin 4
Protein class	Disease related genes Potential drug targets Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to vesicles.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (supported)

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. HPA018028 , HPA020872
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to vesicles.

Main location

Vesicles (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA018028	A-431	Vesicles
	HPA018028	U-2 OS	Vesicles
	HPA018028	U-251 MG	Vesicles
	HPA020872	A-431	Vesicles
	HPA020872	U-2 OS	Vesicles

GENE INFORMATION
Gene name	SFXN4
Synonyms
Description	Sideroflexin 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the sideroflexin family. The encoded protein is a transmembrane protein of the inner mitochondrial membrane, and is required for mitochondrial respiratory homeostasis and erythropoiesis. Mutations in this gene are associated with mitochondriopathy and macrocytic anemia. Alternatively spliced transcript variants have been found in this gene. [provided by RefSeq, Jan 2014]
Chromosome	10
Cytoband	q26.11
Chromosome location (bp)	119140767 - 119165667
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183605 (version 83.38)
Entrez gene	119559
UniProt	Q6P4A7 (UniProt - Evidence at protein level)
neXtProt	NX_Q6P4A7
Antibodypedia	SFXN4 antibodies

PROTEIN BROWSER

SFXN4-001	SFXN4-004	SFXN4-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SFXN4-001 ENSP00000347924 ENST00000355697	Q6P4A7 [Direct mapping] Sideroflexin-4 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005743 [mitochondrial inner membrane] GO:0006811 [ion transport] GO:0015075 [ion transmembrane transporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0043231 [intracellular membrane-bounded organelle] GO:0055072 [iron ion homeostasis] GO:0055085 [transmembrane transport] Show all	337 aa 38 kDa	No	5
SFXN4-004 ENSP00000358127 ENST00000369131	B1AMV7 [Direct mapping] Sideroflexin-4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006811 [ion transport] GO:0015075 [ion transmembrane transporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0043231 [intracellular membrane-bounded organelle] GO:0055085 [transmembrane transport] Show all	178 aa 19.7 kDa	No	2
SFXN4-005 ENSP00000414193 ENST00000419372	B1AMV8 [Direct mapping] Sideroflexin-4 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0015075 [ion transmembrane transporter activity] GO:0016020 [membrane] GO:0034220 [ion transmembrane transport] Show all	63 aa 6.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.