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A majority of cancers showed weak to moderate nuclear positivity. Breast, prostate cancers along with some cases of melanomas and ovarian cancers displayed additional cytoplasmic immunoreactivity. Strong positivity was seen in few cases of seminomas. Many cases of renal cancers and hepatocellular carcinomas were negative.
Most cancer tissues displayed moderate cytoplasmic staining. A few cases of colorectal cancers along with occasional stomach cancers were strongly positive. Several cases of gliomas, skin, renal, pancreatic and cervical cancers were weakly stained or negative.
GENE INFORMATION
Gene name
MRPL54
Synonyms
Description
Mitochondrial ribosomal protein L54 (HGNC Symbol)
Entrez gene summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]
