Tissue expression of CCR3 - Summary - The Human Protein Atlas

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CCR3

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	CCR3
Gene description	Chemokine (C-C motif) receptor 3
Protein class	CD markers G-protein coupled receptors Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Not detected
FANTOM5:	Tissue enhanced (placenta)

Protein evidence

Evidence at protein level

Protein expression

Mainly membrane expression in several tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Uncertain based on 1 antibody. CAB003795
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

N/A

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Not detected
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (placenta)

GENE INFORMATION
Gene name	CCR3 (HGNC Symbol)
Synonyms	CC-CKR-3, CD193, CKR3, CMKBR3
Description	Chemokine (C-C motif) receptor 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2009]
Chromosome	3
Cytoband	p21.31
Chromosome location (bp)	46163604 - 46266706
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183625 (version 83.38)
Entrez gene	1232
UniProt	P51677 (UniProt - Evidence at protein level)
neXtProt	NX_P51677
Antibodypedia	CCR3 antibodies

PROTEIN BROWSER

CCR3-001	CCR3-002	CCR3-003	CCR3-004	CCR3-007	CCR3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CCR3-001 ENSP00000350003 ENST00000357422	P51677 [Direct mapping] C-C chemokine receptor type 3 A0A024R2Z3 [Target identity:100%; Query identity:100%] Chemokine (C-C motif) receptor 3, isoform CRA_a Show all	CD markers G-protein coupled receptors GPCRs excl olfactory receptors Chemokines and chemotactic factors receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004950 [chemokine receptor activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006954 [inflammatory response] GO:0006968 [cellular defense response] GO:0007155 [cell adhesion] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0045766 [positive regulation of angiogenesis] GO:0070098 [chemokine-mediated signaling pathway] Show all	355 aa 41 kDa	No	7
CCR3-002 ENSP00000379271 ENST00000395940	P51677 [Direct mapping] C-C chemokine receptor type 3 A0A024R2Z3 [Target identity:100%; Query identity:100%] Chemokine (C-C motif) receptor 3, isoform CRA_a Show all	CD markers G-protein coupled receptors GPCRs excl olfactory receptors Chemokines and chemotactic factors receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004950 [chemokine receptor activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006954 [inflammatory response] GO:0006968 [cellular defense response] GO:0007155 [cell adhesion] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0045766 [positive regulation of angiogenesis] GO:0070098 [chemokine-mediated signaling pathway] Show all	355 aa 41 kDa	No	7
CCR3-003 ENSP00000389336 ENST00000452454	Q8TDP5 [Direct mapping] C-C chemokine receptor type 3; CC chemokine receptor 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004950 [chemokine receptor activity] GO:0006935 [chemotaxis] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0070098 [chemokine-mediated signaling pathway] Show all	80 aa 9 kDa	No	1
CCR3-004 ENSP00000401822 ENST00000457243	Q8TDP4 [Direct mapping] C-C chemokine receptor type 3; CC chemokine receptor 3 Show all	Predicted intracellular proteins Show all		21 aa 2.3 kDa	No	0
CCR3-007 ENSP00000379273 ENST00000395942	P51677 [Direct mapping] C-C chemokine receptor type 3 A0A024R2Z3 [Target identity:100%; Query identity:100%] Chemokine (C-C motif) receptor 3, isoform CRA_a Show all	CD markers G-protein coupled receptors GPCRs excl olfactory receptors Chemokines and chemotactic factors receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004950 [chemokine receptor activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006954 [inflammatory response] GO:0006968 [cellular defense response] GO:0007155 [cell adhesion] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0045766 [positive regulation of angiogenesis] GO:0070098 [chemokine-mediated signaling pathway] Show all	355 aa 41 kDa	No	7
CCR3-201 ENSP00000441600 ENST00000545097	P51677 [Direct mapping] C-C chemokine receptor type 3 Show all	CD markers G-protein coupled receptors GPCRs excl olfactory receptors Chemokines and chemotactic factors receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0001938 [positive regulation of endothelial cell proliferation] GO:0004930 [G-protein coupled receptor activity] GO:0004950 [chemokine receptor activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006935 [chemotaxis] GO:0006954 [inflammatory response] GO:0006968 [cellular defense response] GO:0007155 [cell adhesion] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0016493 [C-C chemokine receptor activity] GO:0045766 [positive regulation of angiogenesis] GO:0070098 [chemokine-mediated signaling pathway] Show all	376 aa 43.5 kDa	No	7

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.