Cell atlas - MARCH11 - The Human Protein Atlas

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MARCH11

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Vesicles

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	MARCH11
Gene description	Membrane-associated ring finger (C3HC4) 11
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to vesicles.
RNA cell category	Cell line enriched (SH-SY5Y)
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA077262
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (SH-SY5Y) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to vesicles.

Main location

Vesicles (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA077262	U-2 OS	Vesicles

GENE INFORMATION
Gene name	MARCH11 (HGNC Symbol)
Synonyms	MARCH-XI
Description	Membrane-associated ring finger (C3HC4) 11 (HGNC Symbol)
Entrez gene summary	MARCH11 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). These enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their intracellular transport. March11 appears to have a role in ubiquitin-mediated protein sorting in the trans-Golgi network (TGN)-multivesicular body (MVB) transport pathway (Morokuma et al., 2007 [PubMed 17604280]).[supplied by OMIM, Apr 2010]
Chromosome	5
Cytoband	p15.1
Chromosome location (bp)	16067139 - 16180762
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183654 (version 83.38)
Entrez gene	441061
UniProt	A6NNE9 (UniProt - Evidence at transcript level)
neXtProt	NX_A6NNE9
Antibodypedia	MARCH11 antibodies

PROTEIN BROWSER

MARCH11-001	MARCH11-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MARCH11-001 ENSP00000333181 ENST00000332432	A6NNE9 [Direct mapping] E3 ubiquitin-protein ligase MARCH11 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0030659 [cytoplasmic vesicle membrane] Show all	402 aa 43.9 kDa	No	2
MARCH11-002 ENSP00000424425 ENST00000507111	H0Y9K6 [Direct mapping] E3 ubiquitin-protein ligase MARCH11 Show all	Predicted intracellular proteins Show all		54 aa 6.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.