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TRAIP

CANCER ATLAS

Gene description

 TRAF interacting protein

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA036261
HPA036262

GENE INFORMATION

Gene name

 TRAIP (HGNC Symbol)

Synonyms

 RNF206, TRIP

Description

 TRAF interacting protein (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that contains an N-terminal RING finger motif and a putative coiled-coil domain. A similar murine protein interacts with TNFR-associated factor 1 (TRAF1), TNFR-associated factor 2 (TRAF2), and cylindromatosis. The interaction with TRAF2 inhibits TRAF2-mediated nuclear factor kappa-B, subunit 1 activation that is required for cell activation and protection against apoptosis. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 p21.31

Chromosome location (bp)

 49828599 - 49856574

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000183763 (version 83.38)

Entrez gene

 10293

UniProt

 Q9BWF2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BWF2

Antibodypedia

 TRAIP antibodies

PROTEIN BROWSER
TRAIP-001
TRAIP-005
TRAIP-007
TRAIP-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TRAIP-001
ENSP00000328203
ENST00000331456
Q9BWF2 [Direct mapping]
E3 ubiquitin-protein ligase TRAIP
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005057 [receptor signaling protein activity]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0006915 [apoptotic process]
GO:0007165 [signal transduction]
GO:0008270 [zinc ion binding]
GO:0008283 [cell proliferation]
GO:0010804 [negative regulation of tumor necrosis factor-mediated signaling pathway]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0032688 [negative regulation of interferon-beta production]
GO:0035556 [intracellular signal transduction]
GO:0048471 [perinuclear region of cytoplasm]
GO:0061630 [ubiquitin protein ligase activity]
Show all
 469 aa
53.3 kDa 		No 0
TRAIP-005
ENSP00000420085
ENST00000469027
E7ETV1 [Direct mapping]
E3 ubiquitin-protein ligase TRAIP
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0008270 [zinc ion binding]
Show all
 284 aa
31.8 kDa 		No 0
TRAIP-007
ENSP00000418544
ENST00000482582
E7EN91 [Direct mapping]
E3 ubiquitin-protein ligase TRAIP
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0008270 [zinc ion binding]
Show all
 266 aa
30.7 kDa 		No 0
TRAIP-009
ENSP00000419350
ENST00000482243
E7EW89 [Direct mapping]
E3 ubiquitin-protein ligase TRAIP
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0008270 [zinc ion binding]
Show all
 155 aa
18 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.