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Expression has cell cycle dependency according to biological definition
Intensity variation
Cytokinetic bridge
GENE INFORMATION
Gene name
FOXL2 (HGNC Symbol)
Synonyms
BPES, BPES1
Description
Forkhead box L2 (HGNC Symbol)
Entrez gene summary
This gene encodes a forkhead transcription factor. The protein contains a fork-head DNA-binding domain and may play a role in ovarian development and function. Mutations in this gene are a cause of blepharophimosis syndrome and premature ovarian failure 3. [provided by RefSeq, Jun 2009]
Predicted intracellular proteins Transcription factors Helix-turn-helix domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001541 [ovarian follicle development] GO:0001555 [oocyte growth] GO:0002074 [extraocular skeletal muscle development] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006309 [apoptotic DNA fragmentation] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006366 [transcription from RNA polymerase II promoter] GO:0009653 [anatomical structure morphogenesis] GO:0019101 [female somatic sex determination] GO:0030154 [cell differentiation] GO:0030331 [estrogen receptor binding] GO:0031624 [ubiquitin conjugating enzyme binding] GO:0042703 [menstruation] GO:0043028 [cysteine-type endopeptidase regulator activity involved in apoptotic process] GO:0043065 [positive regulation of apoptotic process] GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043565 [sequence-specific DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048048 [embryonic eye morphogenesis] GO:0060014 [granulosa cell differentiation]