Expression of CCR4 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Chemokine (C-C motif) receptor 4

Protein class

CD markers, G-protein coupled receptors, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA031613

GENE INFORMATION
Gene name	CCR4 (HGNC Symbol)
Synonyms	CC-CKR-4, CD194, ChemR13, CKR4, CMKBR4, k5-5
Description	Chemokine (C-C motif) receptor 4 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	p22.3
Chromosome location (bp)	32951574 - 32956349
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183813 (version 83.38)
Entrez gene	1233
UniProt	P51679 (UniProt - Evidence at protein level)
neXtProt	NX_P51679
Antibodypedia	CCR4 antibodies

PROTEIN BROWSER

CCR4-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CCR4-001 ENSP00000332659 ENST00000330953	P51679 [Direct mapping] C-C chemokine receptor type 4 A0N0Q1 [Target identity:100%; Query identity:100%] Chemokine (C-C motif) receptor 4; Chemokine (C-C motif) receptor 4, isoform CRA_a; cDNA FLJ75821, highly similar to Homo sapiens chemokine (C-C motif) receptor 4 (CCR4), mRNA Show all	CD markers G-protein coupled receptors GPCRs excl olfactory receptors Chemokines and chemotactic factors receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0001764 [neuron migration] GO:0002507 [tolerance induction] GO:0004930 [G-protein coupled receptor activity] GO:0004950 [chemokine receptor activity] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006935 [chemotaxis] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0009897 [external side of plasma membrane] GO:0016021 [integral component of membrane] GO:0016493 [C-C chemokine receptor activity] GO:0048872 [homeostasis of number of cells] GO:0070098 [chemokine-mediated signaling pathway] Show all	360 aa 41.4 kDa	No	7