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NUDT14

GENERAL INFORMATION

Gene name

 NUDT14

Gene description

 Nudix (nucleoside diphosphate linked moiety X)-type motif 14

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA046755
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 NUDT14 (HGNC Symbol)

Synonyms

 UGPP

Description

 Nudix (nucleoside diphosphate linked moiety X)-type motif 14 (HGNC Symbol)

Entrez gene summary

 UDP-glucose (UDPG) acts as the sugar donor in numerous glycosylation reactions, including those involved in the production of glycogen. NUDT14 is a UDPG pyrophosphatase (EC 3.6.1.45) that hydrolyzes UDPG to produce glucose 1-phosphate and UMP (Yagi et al., 2003 [PubMed 12429023]).[supplied by OMIM, Mar 2008]

Chromosome

 14

Cytoband

 q32.33

Chromosome location (bp)

 105172938 - 105181323

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000183828 (version 83.38)

Entrez gene

 256281

UniProt

 O95848 (UniProt - Evidence at protein level)

neXtProt

 NX_O95848

Antibodypedia

 NUDT14 antibodies

PROTEIN BROWSER
NUDT14-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NUDT14-001
ENSP00000376349
ENST00000392568
O95848 [Direct mapping]
Uridine diphosphate glucose pyrophosphatase
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Enzymes
   ENZYME proteins
   Hydrolases
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0008152 [metabolic process]
GO:0008768 [UDP-sugar diphosphatase activity]
GO:0016787 [hydrolase activity]
GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides]
GO:0046872 [metal ion binding]
GO:0047631 [ADP-ribose diphosphatase activity]
GO:0070062 [extracellular exosome]
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 222 aa
24.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.