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Most cancers showed moderate to strong nuclear immunoreactivity. A majority of testicular cancers were weakly stained or negative.
GENE INFORMATION
Gene name
PRKX (HGNC Symbol)
Synonyms
PKX1
Description
Protein kinase, X-linked (HGNC Symbol)
Entrez gene summary
This gene encodes a serine threonine protein kinase that has similarity to the catalytic subunit of cyclic AMP dependent protein kinases. The encoded protein is developmentally regulated and may be involved in renal epithelial morphogenesis. This protein may also be involved in macrophage and granulocyte maturation. Abnormal recombination between this gene and a related pseudogene on chromosome Y is a frequent cause of sex reversal disorder in XX males and XY females. Pseudogenes of this gene are found on chromosomes X, 15 and Y. [provided by RefSeq, Feb 2010]
P51817 [Direct mapping] cAMP-dependent protein kinase catalytic subunit PRKX A0A024RBU5 [Target identity:100%; Query identity:100%] Protein kinase, X-linked, isoform CRA_b
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Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
