Tissue expression of SETD8 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SETD8
Gene description	SET domain containing (lysine methyltransferase) 8
Protein class	Enzymes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	SETD8 (HGNC Symbol)
Synonyms	KMT5A, PR-Set7, SET07, SET8
Description	SET domain containing (lysine methyltransferase) 8 (HGNC Symbol)
Entrez gene summary
Chromosome	12
Cytoband	q24.31
Chromosome location (bp)	123383773 - 123409358
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183955 (version 83.38)
Entrez gene	387893
UniProt	Q9NQR1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NQR1
Antibodypedia	SETD8 antibodies

PROTEIN BROWSER

SETD8-001	SETD8-005	SETD8-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SETD8-001 ENSP00000384629 ENST00000402868	Q9NQR1 [Direct mapping] N-lysine methyltransferase SETD8 Show all	Enzymes ENZYME proteins Transferases Phobius predicted secreted proteins Predicted intracellular proteins Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000278 [mitotic cell cycle] GO:0002039 [p53 binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0005730 [nucleolus] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0007067 [mitotic nuclear division] GO:0016279 [protein-lysine N-methyltransferase activity] GO:0018024 [histone-lysine N-methyltransferase activity] GO:0018026 [peptidyl-lysine monomethylation] GO:0034968 [histone lysine methylation] GO:0043516 [regulation of DNA damage response, signal transduction by p53 class mediator] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0051301 [cell division] Show all	352 aa 39.2 kDa	No	0
SETD8-005 ENSP00000413811 ENST00000437502	C9JKQ0 [Direct mapping] N-lysine methyltransferase SETD8 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0018024 [histone-lysine N-methyltransferase activity] GO:0034968 [histone lysine methylation] Show all	299 aa 34 kDa	Yes	0
SETD8-201 ENSP00000332995 ENST00000330479	A0A0C4DFR3 [Direct mapping] N-lysine methyltransferase SETD8 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0018024 [histone-lysine N-methyltransferase activity] GO:0034968 [histone lysine methylation] Show all	322 aa 36.3 kDa	No	0