Tissue expression of DENND5A - Summary - The Human Protein Atlas

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DENND5A

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	DENND5A
Gene description	DENN/MADD domain containing 5A
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several different tissue types.

DATA RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA052923 , HPA055009
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	DENND5A (HGNC Symbol)
Synonyms	FLJ22354, FLJ33829, FLJ43455, KIAA1091, RAB6IP1
Description	DENN/MADD domain containing 5A (HGNC Symbol)
Entrez gene summary
Chromosome	11
Cytoband	p15.4
Chromosome location (bp)	9138825 - 9265390
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000184014 (version 83.38)
Entrez gene	23258
UniProt	Q6IQ26 (UniProt - Evidence at protein level)
neXtProt	NX_Q6IQ26
Antibodypedia	DENND5A antibodies

PROTEIN BROWSER

DENND5A-001	DENND5A-003	DENND5A-011	DENND5A-014	DENND5A-015	DENND5A-016

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DENND5A-001 ENSP00000328524 ENST00000328194	Q6IQ26 [Direct mapping] DENN domain-containing protein 5A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005262 [calcium channel activity] GO:0005515 [protein binding] GO:0005794 [Golgi apparatus] GO:0005802 [trans-Golgi network] GO:0016020 [membrane] GO:0017112 [Rab guanyl-nucleotide exchange factor activity] GO:0017137 [Rab GTPase binding] GO:0030904 [retromer complex] GO:0042147 [retrograde transport, endosome to Golgi] GO:0043547 [positive regulation of GTPase activity] GO:0050982 [detection of mechanical stimulus] GO:0070588 [calcium ion transmembrane transport] Show all	1287 aa 147.1 kDa	No	2
DENND5A-003 ENSP00000435866 ENST00000530044	Q6IQ26 [Direct mapping] DENN domain-containing protein 5A Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005262 [calcium channel activity] GO:0005515 [protein binding] GO:0005802 [trans-Golgi network] GO:0016020 [membrane] GO:0017112 [Rab guanyl-nucleotide exchange factor activity] GO:0030904 [retromer complex] GO:0042147 [retrograde transport, endosome to Golgi] GO:0043547 [positive regulation of GTPase activity] GO:0050982 [detection of mechanical stimulus] GO:0070588 [calcium ion transmembrane transport] Show all	1241 aa 142 kDa	No	0
DENND5A-011 ENSP00000432428 ENST00000524446	H0YCW5 [Direct mapping] DENN domain-containing protein 5A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005262 [calcium channel activity] GO:0005515 [protein binding] GO:0016020 [membrane] GO:0050982 [detection of mechanical stimulus] GO:0070588 [calcium ion transmembrane transport] Show all	189 aa 21.7 kDa	No	1
DENND5A-014 ENSP00000433483 ENST00000525784	H0YDE6 [Direct mapping] DENN domain-containing protein 5A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005262 [calcium channel activity] GO:0005515 [protein binding] GO:0016020 [membrane] GO:0050982 [detection of mechanical stimulus] GO:0070588 [calcium ion transmembrane transport] Show all	261 aa 29.6 kDa	No	0
DENND5A-015 ENSP00000435368 ENST00000533737	H0YEA8 [Direct mapping] DENN domain-containing protein 5A Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005262 [calcium channel activity] GO:0016020 [membrane] GO:0050982 [detection of mechanical stimulus] GO:0070588 [calcium ion transmembrane transport] Show all	195 aa 22.2 kDa	No	0
DENND5A-016 ENSP00000434237 ENST00000528725	H0YDS8 [Direct mapping] DENN domain-containing protein 5A Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005262 [calcium channel activity] GO:0016020 [membrane] GO:0050982 [detection of mechanical stimulus] GO:0070588 [calcium ion transmembrane transport] Show all	186 aa 20.8 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.