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DSCR4

GENERAL INFORMATION

Gene name

 DSCR4

Gene description

 Down syndrome critical region 4

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (placenta, testis)
GTEx:Not detected
FANTOM5:Tissue enriched (placenta)

Protein evidence

 Evidence at transcript level

Protein expression

 Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA018460
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (placenta, testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Not detected
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (placenta)

GENE INFORMATION

Gene name

 DSCR4 (HGNC Symbol)

Synonyms

 DCRB

Description

 Down syndrome critical region 4 (HGNC Symbol)

Entrez gene summary

 The gene is found in a region of chromosome 21 that has been linked to the pathogenesis of Down syndrome. This gene is transcribed from a bi-directional promoter located in an endogenous retrovirus. [provided by RefSeq, Jan 2015]

Chromosome

 21

Cytoband

 q22.13

Chromosome location (bp)

 37951425 - 38121360

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000184029 (version 83.38)

Entrez gene

 10281

UniProt

 P56555 (UniProt - Evidence at transcript level)

neXtProt

 NX_P56555

Antibodypedia

 DSCR4 antibodies

PROTEIN BROWSER
DSCR4-001
DSCR4-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DSCR4-001
ENSP00000328676
ENST00000328264
P56555 [Direct mapping]
Down syndrome critical region protein 4
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Predicted intracellular proteins
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GO:0003674 [molecular_function]
GO:0005575 [cellular_component]
GO:0008150 [biological_process]
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 118 aa
13 kDa 		No 0
DSCR4-002
ENSP00000381921
ENST00000398948
A8MZ14 [Direct mapping]
Down syndrome critical region protein 4
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Predicted intracellular proteins
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 127 aa
13.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.