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ADRA2C

GENERAL INFORMATION

Gene name

 ADRA2C

Gene description

 Adrenoceptor alpha 2C

Protein class

 FDA approved drug targets
G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (seminal vesicle, endometrium, cervix, uterine)
GTEx:Tissue enhanced (cervix, uterine)
FANTOM5:Mixed

Protein evidence

 Evidence at transcript level

Protein expression

 Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA057688
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (seminal vesicle, endometrium, cervix, uterine)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cervix, uterine)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 ADRA2C (HGNC Symbol)

Synonyms

 ADRA2L2, ADRA2RL2, ADRARL2

Description

 Adrenoceptor alpha 2C (HGNC Symbol)

Entrez gene summary

 Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 p16.3

Chromosome location (bp)

 3766348 - 3768526

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000184160 (version 83.38)

Entrez gene

 152

UniProt

 P18825 (UniProt - Evidence at transcript level)

neXtProt

 NX_P18825

Antibodypedia

 ADRA2C antibodies

PROTEIN BROWSER
ADRA2C-001
ADRA2C-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ADRA2C-001
ENSP00000426268
ENST00000509482
D6RGL0 [Direct mapping]
Alpha-2C adrenergic receptor
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0004938 [alpha2-adrenergic receptor activity]
GO:0005886 [plasma membrane]
GO:0006940 [regulation of smooth muscle contraction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007194 [negative regulation of adenylate cyclase activity]
GO:0016021 [integral component of membrane]
GO:0019229 [regulation of vasoconstriction]
GO:0030168 [platelet activation]
GO:0061179 [negative regulation of insulin secretion involved in cellular response to glucose stimulus]
GO:0071881 [adenylate cyclase-inhibiting adrenergic receptor signaling pathway]
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 374 aa
38.5 kDa 		Yes 5
ADRA2C-002
ENSP00000386069
ENST00000330055
P18825 [Direct mapping]
Alpha-2C adrenergic receptor
Q4W594 [Target identity:100%; Query identity:100%]
Adrenergic, alpha-2C-, receptor; Putative uncharacterized protein ADRA2C
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G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0004938 [alpha2-adrenergic receptor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007194 [negative regulation of adenylate cyclase activity]
GO:0007267 [cell-cell signaling]
GO:0007565 [female pregnancy]
GO:0007596 [blood coagulation]
GO:0010700 [negative regulation of norepinephrine secretion]
GO:0016021 [integral component of membrane]
GO:0030168 [platelet activation]
GO:0030424 [axon]
GO:0031694 [alpha-2A adrenergic receptor binding]
GO:0032148 [activation of protein kinase B activity]
GO:0032811 [negative regulation of epinephrine secretion]
GO:0035625 [epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway]
GO:0042803 [protein homodimerization activity]
GO:0043679 [axon terminus]
GO:0044281 [small molecule metabolic process]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045907 [positive regulation of vasoconstriction]
GO:0046982 [protein heterodimerization activity]
GO:0050796 [regulation of insulin secretion]
GO:0051379 [epinephrine binding]
GO:0051930 [regulation of sensory perception of pain]
GO:0061179 [negative regulation of insulin secretion involved in cellular response to glucose stimulus]
GO:0070473 [negative regulation of uterine smooth muscle contraction]
GO:0071881 [adenylate cyclase-inhibiting adrenergic receptor signaling pathway]
GO:0071883 [activation of MAPK activity by adrenergic receptor signaling pathway]
Show all
 462 aa
49.5 kDa 		Yes 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.