Expression of KCNJ12 in cancer - Summary

CANCER ATLAS

Gene description

Potassium channel, inwardly rectifying subfamily J, member 12

Protein class

FDA approved drug targets, Predicted membrane proteins, Voltage-gated ion channels

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

STAINING SUMMARY

HPA027021

GENE INFORMATION
Gene name	KCNJ12 (HGNC Symbol)
Synonyms	hIRK1, IRK2, KCNJN1, Kir2.2, Kir2.2v
Description	Potassium channel, inwardly rectifying subfamily J, member 12 (HGNC Symbol)
Entrez gene summary	This gene encodes an inwardly rectifying K+ channel which may be blocked by divalent cations. This protein is thought to be one of multiple inwardly rectifying channels which contribute to the cardiac inward rectifier current (IK1). The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	p11.2
Chromosome location (bp)	21376197 - 21419872
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000184185 (version 83.38)
Entrez gene	3768
UniProt	Q14500 (UniProt - Evidence at protein level)
neXtProt	NX_Q14500
Antibodypedia	KCNJ12 antibodies

PROTEIN BROWSER

KCNJ12-001	KCNJ12-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCNJ12-001 ENSP00000463778 ENST00000583088	Q14500 [Direct mapping] ATP-sensitive inward rectifier potassium channel 12 Show all	Voltage-gated ion channels Inwardly Rectifying Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0005242 [inward rectifier potassium channel activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006813 [potassium ion transport] GO:0006936 [muscle contraction] GO:0007268 [synaptic transmission] GO:0008016 [regulation of heart contraction] GO:0010107 [potassium ion import] GO:0016021 [integral component of membrane] GO:0031224 [intrinsic component of membrane] GO:0034765 [regulation of ion transmembrane transport] GO:0051289 [protein homotetramerization] Show all	433 aa 49 kDa	No	3
KCNJ12-002 ENSP00000328150 ENST00000331718	Q14500 [Direct mapping] ATP-sensitive inward rectifier potassium channel 12 Show all	Voltage-gated ion channels Inwardly Rectifying Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0005242 [inward rectifier potassium channel activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006813 [potassium ion transport] GO:0006936 [muscle contraction] GO:0007268 [synaptic transmission] GO:0008016 [regulation of heart contraction] GO:0010107 [potassium ion import] GO:0016021 [integral component of membrane] GO:0031224 [intrinsic component of membrane] GO:0034765 [regulation of ion transmembrane transport] GO:0051289 [protein homotetramerization] Show all	433 aa 49 kDa	No	3