Cell atlas - TSSC4 - The Human Protein Atlas

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TSSC4

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	TSSC4
Gene description	Tumor suppressing subtransferable candidate 4
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)
Additional location	In addition localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA058763
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the cytosol.

Main location

Nucleoplasm (approved)

Additional location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA058763	A-431	Nucleoplasm
	HPA058763	U-2 OS	Nucleoplasm
	HPA058763	U-251 MG	Nucleoplasm
	HPA058763	U-251 MG	Cytosol

GENE INFORMATION
Gene name	TSSC4
Synonyms
Description	Tumor suppressing subtransferable candidate 4 (HGNC Symbol)
Entrez gene summary	This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene is located among several imprinted genes; however, this gene, as well as the pan-hematopoietic expression gene (PHEMX), escapes imprinting. This gene may play a role in malignancies and disease that involve this region. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Chromosome	11
Cytoband	p15.5
Chromosome location (bp)	2400488 - 2403878
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000184281 (version 83.38)
Entrez gene	10078
UniProt	Q9Y5U2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y5U2
Antibodypedia	TSSC4 antibodies

PROTEIN BROWSER

TSSC4-001	TSSC4-002	TSSC4-003	TSSC4-004	TSSC4-005	TSSC4-006	TSSC4-007	TSSC4-008	TSSC4-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TSSC4-001 ENSP00000331087 ENST00000333256	Q9Y5U2 [Direct mapping] Protein TSSC4 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	329 aa 34.3 kDa	No	0
TSSC4-002 ENSP00000370384 ENST00000380996	Q9Y5U2 [Direct mapping] Protein TSSC4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	265 aa 27.9 kDa	No	0
TSSC4-003 ENSP00000370380 ENST00000380992	A6NCC9 [Direct mapping] Protein TSSC4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		127 aa 13.8 kDa	No	0
TSSC4-004 ENSP00000396925 ENST00000437110	C9JHT9 [Direct mapping] Protein TSSC4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		203 aa 21.2 kDa	No	0
TSSC4-005 ENSP00000403475 ENST00000435795	C9JDU0 [Direct mapping] Protein TSSC4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		112 aa 11.5 kDa	No	0
TSSC4-006 ENSP00000416937 ENST00000440813	C9JJV1 [Direct mapping] Protein TSSC4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		208 aa 22 kDa	No	0
TSSC4-007 ENSP00000431430 ENST00000485682	E9PL88 [Direct mapping] Protein TSSC4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		110 aa 11.3 kDa	No	0
TSSC4-008 ENSP00000435013 ENST00000496468	E9PME3 [Direct mapping] Protein TSSC4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		191 aa 20 kDa	No	0
TSSC4-201 ENSP00000411224 ENST00000451491	Q9Y5U2 [Direct mapping] Protein TSSC4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	329 aa 34.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.