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CSF1

GENERAL INFORMATION

Gene name

 CSF1

Gene description

 Colony stimulating factor 1 (macrophage)

Protein class

 Cancer-related genes
Candidate cardiovascular disease genes
Disease related genes
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins
RAS pathway related proteins

Predicted localization

 Intracellular,Membrane,Secreted

Number of transcripts

 8
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CSF1 (HGNC Symbol)

Synonyms

 M-CSF, MCSF, MGC31930

Description

 Colony stimulating factor 1 (macrophage) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. The encoded protein may be involved in development of the placenta. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]

Chromosome

 1

Cytoband

 p13.3

Chromosome location (bp)

 109910242 - 109930992

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000184371 (version 83.38)

Entrez gene

 1435

UniProt

 P09603 (UniProt - Evidence at protein level)

neXtProt

 NX_P09603

Antibodypedia

 CSF1 antibodies

PROTEIN BROWSER
CSF1-001
CSF1-002
CSF1-003
CSF1-004
CSF1-005
CSF1-006
CSF1-007
CSF1-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CSF1-001
ENSP00000327513
ENST00000329608
P09603 [Direct mapping]
Macrophage colony-stimulating factor 1 Processed macrophage colony-stimulating factor 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001503 [ossification]
GO:0001954 [positive regulation of cell-matrix adhesion]
GO:0002158 [osteoclast proliferation]
GO:0003006 [developmental process involved in reproduction]
GO:0005125 [cytokine activity]
GO:0005157 [macrophage colony-stimulating factor receptor binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0006954 [inflammatory response]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0008083 [growth factor activity]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0010628 [positive regulation of gene expression]
GO:0010743 [regulation of macrophage derived foam cell differentiation]
GO:0010744 [positive regulation of macrophage derived foam cell differentiation]
GO:0010759 [positive regulation of macrophage chemotaxis]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030097 [hemopoiesis]
GO:0030154 [cell differentiation]
GO:0030225 [macrophage differentiation]
GO:0030278 [regulation of ossification]
GO:0030316 [osteoclast differentiation]
GO:0030335 [positive regulation of cell migration]
GO:0032270 [positive regulation of cellular protein metabolic process]
GO:0032946 [positive regulation of mononuclear cell proliferation]
GO:0038145 [macrophage colony-stimulating factor signaling pathway]
GO:0040018 [positive regulation of multicellular organism growth]
GO:0042117 [monocyte activation]
GO:0042476 [odontogenesis]
GO:0042488 [positive regulation of odontogenesis of dentin-containing tooth]
GO:0042803 [protein homodimerization activity]
GO:0045087 [innate immune response]
GO:0045651 [positive regulation of macrophage differentiation]
GO:0045657 [positive regulation of monocyte differentiation]
GO:0045672 [positive regulation of osteoclast differentiation]
GO:0045860 [positive regulation of protein kinase activity]
GO:0046579 [positive regulation of Ras protein signal transduction]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048873 [homeostasis of number of cells within a tissue]
GO:0060444 [branching involved in mammary gland duct morphogenesis]
GO:0060611 [mammary gland fat development]
GO:0060763 [mammary duct terminal end bud growth]
GO:0070062 [extracellular exosome]
GO:1902228 [positive regulation of macrophage colony-stimulating factor signaling pathway]
GO:1904141 [positive regulation of microglial cell migration]
GO:1990682 [CSF1-CSF1R complex]
Show all
 554 aa
60.2 kDa 		Yes 1
CSF1-002
ENSP00000358817
ENST00000369802
P09603 [Direct mapping]
Macrophage colony-stimulating factor 1 Processed macrophage colony-stimulating factor 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001954 [positive regulation of cell-matrix adhesion]
GO:0003006 [developmental process involved in reproduction]
GO:0005125 [cytokine activity]
GO:0005157 [macrophage colony-stimulating factor receptor binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0006954 [inflammatory response]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0008083 [growth factor activity]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0010628 [positive regulation of gene expression]
GO:0010743 [regulation of macrophage derived foam cell differentiation]
GO:0010744 [positive regulation of macrophage derived foam cell differentiation]
GO:0010759 [positive regulation of macrophage chemotaxis]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030097 [hemopoiesis]
GO:0030154 [cell differentiation]
GO:0030225 [macrophage differentiation]
GO:0030316 [osteoclast differentiation]
GO:0030335 [positive regulation of cell migration]
GO:0032270 [positive regulation of cellular protein metabolic process]
GO:0032946 [positive regulation of mononuclear cell proliferation]
GO:0042117 [monocyte activation]
GO:0042803 [protein homodimerization activity]
GO:0045087 [innate immune response]
GO:0045651 [positive regulation of macrophage differentiation]
GO:0045657 [positive regulation of monocyte differentiation]
GO:0045672 [positive regulation of osteoclast differentiation]
GO:0045860 [positive regulation of protein kinase activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0070062 [extracellular exosome]
GO:1902228 [positive regulation of macrophage colony-stimulating factor signaling pathway]
GO:1904141 [positive regulation of microglial cell migration]
GO:1990682 [CSF1-CSF1R complex]
Show all
 554 aa
60.2 kDa 		Yes 1
CSF1-003
ENSP00000358816
ENST00000369801
P09603 [Direct mapping]
Macrophage colony-stimulating factor 1 Processed macrophage colony-stimulating factor 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001954 [positive regulation of cell-matrix adhesion]
GO:0003006 [developmental process involved in reproduction]
GO:0005125 [cytokine activity]
GO:0005157 [macrophage colony-stimulating factor receptor binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0006954 [inflammatory response]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0008083 [growth factor activity]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0010628 [positive regulation of gene expression]
GO:0010743 [regulation of macrophage derived foam cell differentiation]
GO:0010744 [positive regulation of macrophage derived foam cell differentiation]
GO:0010759 [positive regulation of macrophage chemotaxis]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030097 [hemopoiesis]
GO:0030154 [cell differentiation]
GO:0030225 [macrophage differentiation]
GO:0030316 [osteoclast differentiation]
GO:0030335 [positive regulation of cell migration]
GO:0032270 [positive regulation of cellular protein metabolic process]
GO:0032946 [positive regulation of mononuclear cell proliferation]
GO:0042117 [monocyte activation]
GO:0042803 [protein homodimerization activity]
GO:0045087 [innate immune response]
GO:0045651 [positive regulation of macrophage differentiation]
GO:0045657 [positive regulation of monocyte differentiation]
GO:0045672 [positive regulation of osteoclast differentiation]
GO:0045860 [positive regulation of protein kinase activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0070062 [extracellular exosome]
GO:1902228 [positive regulation of macrophage colony-stimulating factor signaling pathway]
GO:1904141 [positive regulation of microglial cell migration]
GO:1990682 [CSF1-CSF1R complex]
Show all
 438 aa
47.9 kDa 		Yes 1
CSF1-004
ENSP00000407317
ENST00000420111
P09603 [Direct mapping]
Macrophage colony-stimulating factor 1 Processed macrophage colony-stimulating factor 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001954 [positive regulation of cell-matrix adhesion]
GO:0003006 [developmental process involved in reproduction]
GO:0005125 [cytokine activity]
GO:0005157 [macrophage colony-stimulating factor receptor binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0006954 [inflammatory response]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0008083 [growth factor activity]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0010628 [positive regulation of gene expression]
GO:0010743 [regulation of macrophage derived foam cell differentiation]
GO:0010744 [positive regulation of macrophage derived foam cell differentiation]
GO:0010759 [positive regulation of macrophage chemotaxis]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030097 [hemopoiesis]
GO:0030154 [cell differentiation]
GO:0030225 [macrophage differentiation]
GO:0030316 [osteoclast differentiation]
GO:0030335 [positive regulation of cell migration]
GO:0032270 [positive regulation of cellular protein metabolic process]
GO:0032946 [positive regulation of mononuclear cell proliferation]
GO:0042117 [monocyte activation]
GO:0042803 [protein homodimerization activity]
GO:0045087 [innate immune response]
GO:0045651 [positive regulation of macrophage differentiation]
GO:0045657 [positive regulation of monocyte differentiation]
GO:0045672 [positive regulation of osteoclast differentiation]
GO:0045860 [positive regulation of protein kinase activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0070062 [extracellular exosome]
GO:1902228 [positive regulation of macrophage colony-stimulating factor signaling pathway]
GO:1904141 [positive regulation of microglial cell migration]
GO:1990682 [CSF1-CSF1R complex]
Show all
 256 aa
29.2 kDa 		Yes 1
CSF1-005
ENSP00000433837
ENST00000488198
E9PJA2 [Direct mapping]
Macrophage colony-stimulating factor 1
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005125 [cytokine activity]
GO:0008083 [growth factor activity]
GO:0016021 [integral component of membrane]
Show all
 285 aa
31.2 kDa 		No 0
CSF1-006
ENSP00000434527
ENST00000527192
E9PQ08 [Direct mapping]
Macrophage colony-stimulating factor 1
Show all
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005125 [cytokine activity]
GO:0008083 [growth factor activity]
GO:0016021 [integral component of membrane]
Show all
 150 aa
17.3 kDa 		Yes 0
CSF1-007
ENSP00000431547
ENST00000525659
E9PKP4 [Direct mapping]
Macrophage colony-stimulating factor 1
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005125 [cytokine activity]
GO:0008083 [growth factor activity]
GO:0016021 [integral component of membrane]
Show all
 113 aa
13.3 kDa 		No 0
CSF1-008
ENSP00000349854
ENST00000357302
H7BY18 [Direct mapping]
Macrophage colony-stimulating factor 1
Show all
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005125 [cytokine activity]
GO:0008083 [growth factor activity]
GO:0016021 [integral component of membrane]
Show all
 119 aa
13.4 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.