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Most cancers showed moderate to strong cytoplasmic positivity. Lymphomas, gliomas and liver cancers were weakly stained or negative.
GENE INFORMATION
Gene name
PLA2G6 (HGNC Symbol)
Synonyms
iPLA2, iPLA2beta, NBIA2, PARK14, PNPLA9
Description
Phospholipase A2, group VI (cytosolic, calcium-independent) (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and transmembrane ion flux in glucose-stimulated B-cells. Several transcript variants encoding multiple isoforms have been described, but the full-length nature of only three of them have been determined to date. [provided by RefSeq, Dec 2010]
Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM RAS pathway related proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001934 [positive regulation of protein phosphorylation] GO:0004623 [phospholipase A2 activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005815 [microtubule organizing center] GO:0005829 [cytosol] GO:0006629 [lipid metabolic process] GO:0006644 [phospholipid metabolic process] GO:0006935 [chemotaxis] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007613 [memory] GO:0008152 [metabolic process] GO:0014832 [urinary bladder smooth muscle contraction] GO:0016020 [membrane] GO:0016042 [lipid catabolic process] GO:0019731 [antibacterial humoral response] GO:0019901 [protein kinase binding] GO:0032049 [cardiolipin biosynthetic process] GO:0034976 [response to endoplasmic reticulum stress] GO:0035774 [positive regulation of insulin secretion involved in cellular response to glucose stimulus] GO:0035965 [cardiolipin acyl-chain remodeling] GO:0036151 [phosphatidylcholine acyl-chain remodeling] GO:0036152 [phosphatidylethanolamine acyl-chain remodeling] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0043008 [ATP-dependent protein binding] GO:0044281 [small molecule metabolic process] GO:0045087 [innate immune response] GO:0045909 [positive regulation of vasodilation] GO:0045921 [positive regulation of exocytosis] GO:0046474 [glycerophospholipid biosynthetic process] GO:0047499 [calcium-independent phospholipase A2 activity] GO:0051967 [negative regulation of synaptic transmission, glutamatergic] GO:0060135 [maternal process involved in female pregnancy] GO:0090037 [positive regulation of protein kinase C signaling] GO:0090200 [positive regulation of release of cytochrome c from mitochondria] GO:0090238 [positive regulation of arachidonic acid secretion] GO:1901339 [regulation of store-operated calcium channel activity] GO:2000304 [positive regulation of ceramide biosynthetic process]
Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM RAS pathway related proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM RAS pathway related proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
