Expression of KCND2 in cancer - Summary

CANCER ATLAS

Gene description

Potassium channel, voltage gated Shal related subfamily D, member 2

Protein class

Disease related genes, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA029068

GENE INFORMATION
Gene name	KCND2 (HGNC Symbol)
Synonyms	KIAA1044, Kv4.2, RK5
Description	Potassium channel, voltage gated Shal related subfamily D, member 2 (HGNC Symbol)
Entrez gene summary	Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member mediates a rapidly inactivating, A-type outward potassium current which is not under the control of the N terminus as it is in Shaker channels. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	q31.31
Chromosome location (bp)	120273668 - 120750331
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000184408 (version 83.38)
Entrez gene	3751
UniProt	Q9NZV8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NZV8
Antibodypedia	KCND2 antibodies

PROTEIN BROWSER

KCND2-001	KCND2-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCND2-001 ENSP00000333496 ENST00000331113	Q9NZV8 [Direct mapping] Potassium voltage-gated channel subfamily D member 2 A4D0V9 [Target identity:100%; Query identity:100%] Potassium voltage-gated channel, Shal-related subfamily, member 2 Show all	Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0001508 [action potential] GO:0005216 [ion channel activity] GO:0005249 [voltage-gated potassium channel activity] GO:0005250 [A-type (transient outward) potassium channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0007268 [synaptic transmission] GO:0008076 [voltage-gated potassium channel complex] GO:0016020 [membrane] GO:0019228 [neuronal action potential] GO:0019233 [sensory perception of pain] GO:0030054 [cell junction] GO:0030425 [dendrite] GO:0031226 [intrinsic component of plasma membrane] GO:0032809 [neuronal cell body membrane] GO:0034765 [regulation of ion transmembrane transport] GO:0043025 [neuronal cell body] GO:0043197 [dendritic spine] GO:0043204 [perikaryon] GO:0044853 [plasma membrane raft] GO:0045211 [postsynaptic membrane] GO:0045475 [locomotor rhythm] GO:0046872 [metal ion binding] GO:0051260 [protein homooligomerization] GO:0055085 [transmembrane transport] GO:0071456 [cellular response to hypoxia] GO:0071805 [potassium ion transmembrane transport] Show all	630 aa 70.5 kDa	Yes	6
KCND2-002 ENSP00000415463 ENST00000425288	H7C445 [Direct mapping] Potassium voltage-gated channel subfamily D member 2 Show all	Predicted intracellular proteins Show all	GO:0008076 [voltage-gated potassium channel complex] GO:0071805 [potassium ion transmembrane transport] Show all	177 aa 19.5 kDa	No	0