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Most cancer cells showed moderate to strong cytoplasmic positivity. Several cases of renal cancers and gliomas were weakly stained.
GENE INFORMATION
Gene name
TOP1MT
Synonyms
Description
Topoisomerase (DNA) I, mitochondrial (HGNC Symbol)
Entrez gene summary
This gene encodes a mitochondrial DNA topoisomerase that plays a role in the modification of DNA topology. The encoded protein is a type IB topoisomerase and catalyzes the transient breaking and rejoining of DNA to relieve tension and DNA supercoiling generated in the mitochondrial genome during replication and transcription. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
Q969P6 [Direct mapping] DNA topoisomerase I, mitochondrial E5KMK7 [Target identity:100%; Query identity:100%] Mitochondrial DNA topoisomerase I
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Enzymes ENZYME proteins Isomerase Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Q969P6 [Direct mapping] DNA topoisomerase I, mitochondrial
Show all
Enzymes ENZYME proteins Isomerase Predicted intracellular proteins FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014)
Q969P6 [Direct mapping] DNA topoisomerase I, mitochondrial
Show all
Enzymes ENZYME proteins Isomerase Predicted intracellular proteins FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014)
Q969P6 [Direct mapping] DNA topoisomerase I, mitochondrial
Show all
Enzymes ENZYME proteins Isomerase Predicted intracellular proteins FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014)
