Cell atlas - CCR10 - The Human Protein Atlas

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CCR10

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Endoplasmic reticulum

Human cell
	Endoplasmic Reticulum

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GENERAL INFORMATION
Gene name	CCR10
Gene description	Chemokine (C-C motif) receptor 10
Protein class	Cancer-related genes G-protein coupled receptors Plasma proteins Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the endoplasmic reticulum.
RNA cell category	Cell line enhanced (U-266/70)
Protein evidence	Evidence at protein level
Main location	Localized to the Endoplasmic reticulum (supported)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. HPA048007 , HPA069188
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-266/70) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the endoplasmic reticulum.

Main location

Endoplasmic reticulum (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA048007	HeLa	Endoplasmic reticulum	Intensity
	HPA069188	HeLa	Endoplasmic reticulum	Intensity

GENE INFORMATION
Gene name	CCR10 (HGNC Symbol)
Synonyms	GPR2
Description	Chemokine (C-C motif) receptor 10 (HGNC Symbol)
Entrez gene summary	Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CCR10 is the receptor for CCL27 (SCYA27; MIM 604833); CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation (Homey et al., 2002 [PubMed 11821900]).[supplied by OMIM, Mar 2008]
Chromosome	17
Cytoband	q21.2
Chromosome location (bp)	42678889 - 42683917
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000184451 (version 83.38)
Entrez gene	2826
UniProt	P46092 (UniProt - Evidence at protein level)
neXtProt	NX_P46092
Antibodypedia	CCR10 antibodies

PROTEIN BROWSER

CCR10-001	CCR10-002	CCR10-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CCR10-001 ENSP00000332504 ENST00000332438	P46092 [Direct mapping] C-C chemokine receptor type 10 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Chemokines and chemotactic factors receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004950 [chemokine receptor activity] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006935 [chemotaxis] GO:0006955 [immune response] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0016493 [C-C chemokine receptor activity] GO:0070098 [chemokine-mediated signaling pathway] Show all	362 aa 38.4 kDa	No	7
CCR10-002 ENSP00000468135 ENST00000591765	K7ER70 [Direct mapping] C-C chemokine receptor type 10 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0006935 [chemotaxis] GO:0006955 [immune response] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0016493 [C-C chemokine receptor activity] GO:0070098 [chemokine-mediated signaling pathway] Show all	140 aa 15.3 kDa	No	2
CCR10-003 ENSP00000467331 ENST00000591568	K7EPC9 [Direct mapping] C-C chemokine receptor type 10 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] Show all	83 aa 8.8 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.