Cell atlas - CEND1 - The Human Protein Atlas

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CEND1

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria

Human cell
	Mitochondria

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GENERAL INFORMATION
Gene name	CEND1
Gene description	Cell cycle exit and neuronal differentiation 1
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the mitochondria.
RNA cell category	Cell line enhanced (SCLC-21H, U-87 MG, Karpas-707, SH-SY5Y)
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA042527
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SCLC-21H, U-87 MG, Karpas-707, SH-SY5Y) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the mitochondria.

Main location

Mitochondria (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA042527	SH-SY5Y	Mitochondria	Intensity
	HPA042527	U-251 MG	No staining

GENE INFORMATION
Gene name	CEND1 (HGNC Symbol)
Synonyms	BM88, FLJ90066
Description	Cell cycle exit and neuronal differentiation 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a neuron-specific protein. The similar protein in pig enhances neuroblastoma cell differentiation in vitro and may be involved in neuronal differentiation in vivo. Multiple pseudogenes have been reported for this gene. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	p15.5
Chromosome location (bp)	787104 - 790123
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000184524 (version 83.38)
Entrez gene	51286
UniProt	Q8N111 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8N111
Antibodypedia	CEND1 antibodies

PROTEIN BROWSER

CEND1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CEND1-001 ENSP00000328336 ENST00000330106	Q8N111 [Direct mapping] Cell cycle exit and neuronal differentiation protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0007628 [adult walking behavior] GO:0016021 [integral component of membrane] GO:0021686 [cerebellar granular layer maturation] GO:0021702 [cerebellar Purkinje cell differentiation] GO:0021933 [radial glia guided migration of cerebellar granule cell] GO:0021941 [negative regulation of cerebellar granule cell precursor proliferation] Show all	149 aa 15 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.