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C6orf58

GENERAL INFORMATION

Gene name

 C6orf58

Gene description

 Chromosome 6 open reading frame 58

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (duodenum, stomach, salivary gland)
GTEx:Tissue enriched (salivary gland)
FANTOM5:Tissue enriched (salivary gland)

Protein evidence

 Evidence at protein level

Protein expression

 Distinct cytoplasmic expression in salivary gland, peribronchial glands, subset of cells in stomach mucosa and Brunner's glands of duodenum.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA036263 , HPA041449
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Duodenum

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (duodenum, stomach, salivary gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (salivary gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (salivary gland)

GENE INFORMATION

Gene name

 C6orf58

Synonyms

Description

 Chromosome 6 open reading frame 58 (HGNC Symbol)

Entrez gene summary

Chromosome

 6

Cytoband

 q22.33

Chromosome location (bp)

 127519455 - 127591817

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000184530 (version 83.38)

Entrez gene

 352999

UniProt

 Q6P5S2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6P5S2

Antibodypedia

 C6orf58 antibodies

PROTEIN BROWSER
C6orf58-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
C6orf58-002
ENSP00000328069
ENST00000329722
Q6P5S2 [Direct mapping]
Protein LEG1 homolog
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005615 [extracellular space]
GO:0007275 [multicellular organismal development]
GO:0070062 [extracellular exosome]
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 330 aa
37.9 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.