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SOCS3

CANCER ATLAS

Gene description

 Suppressor of cytokine signaling 3

Protein class

 Disease related genes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB012220

GENE INFORMATION

Gene name

 SOCS3 (HGNC Symbol)

Synonyms

 CIS3, Cish3, SOCS-3, SSI-3

Description

 Suppressor of cytokine signaling 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q25.3

Chromosome location (bp)

 78356778 - 78360077

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000184557 (version 83.38)

Entrez gene

 9021

UniProt

 O14543 (UniProt - Evidence at protein level)

neXtProt

 NX_O14543

Antibodypedia

 SOCS3 antibodies

PROTEIN BROWSER
SOCS3-001
SOCS3-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SOCS3-001
ENSP00000330341
ENST00000330871
O14543 [Direct mapping]
Suppressor of cytokine signaling 3
Q6FI39 [Target identity:100%; Query identity:100%]
SOCS3 protein; Suppressor of cytokine signaling 3, isoform CRA_a; cDNA, FLJ94944, highly similar to Homo sapiens suppressor of cytokine signaling 3 (SOCS3), mRNA
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Predicted intracellular proteins
Disease related genes
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GO:0001666 [response to hypoxia]
GO:0001932 [regulation of protein phosphorylation]
GO:0004860 [protein kinase inhibitor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007259 [JAK-STAT cascade]
GO:0007568 [aging]
GO:0009408 [response to heat]
GO:0009617 [response to bacterium]
GO:0009725 [response to hormone]
GO:0009968 [negative regulation of signal transduction]
GO:0010332 [response to gamma radiation]
GO:0014070 [response to organic cyclic compound]
GO:0016567 [protein ubiquitination]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031100 [organ regeneration]
GO:0032094 [response to food]
GO:0032355 [response to estradiol]
GO:0032496 [response to lipopolysaccharide]
GO:0032570 [response to progesterone]
GO:0032868 [response to insulin]
GO:0034097 [response to cytokine]
GO:0035556 [intracellular signal transduction]
GO:0040008 [regulation of growth]
GO:0042493 [response to drug]
GO:0043066 [negative regulation of apoptotic process]
GO:0043434 [response to peptide hormone]
GO:0045595 [regulation of cell differentiation]
GO:0045597 [positive regulation of cell differentiation]
GO:0046426 [negative regulation of JAK-STAT cascade]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
GO:0050728 [negative regulation of inflammatory response]
GO:0051384 [response to glucocorticoid]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060334 [regulation of interferon-gamma-mediated signaling pathway]
GO:0060337 [type I interferon signaling pathway]
GO:0060338 [regulation of type I interferon-mediated signaling pathway]
GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway]
GO:0060670 [branching involved in labyrinthine layer morphogenesis]
GO:0060674 [placenta blood vessel development]
GO:0060707 [trophoblast giant cell differentiation]
GO:0060708 [spongiotrophoblast differentiation]
GO:1904030 [negative regulation of cyclin-dependent protein kinase activity]
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 225 aa
24.8 kDa 		No 0
SOCS3-002
ENSP00000464727
ENST00000587578
K7EIF6 [Direct mapping]
Suppressor of cytokine-signaling 3
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Predicted intracellular proteins
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GO:0005737 [cytoplasm]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0046426 [negative regulation of JAK-STAT cascade]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
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 16 aa
1.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.