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Most cancer cells showed moderate membranous immunoreactivity. Few cases of breast, colorectal, prostate, testis and urothelial cancers displayed strong positivity. Lymphomas, gliomas and most liver cancers were negative.
This gene encodes a member of the PIWI subfamily of Argonaute family proteins. This subfamily of proteins contains a PAZ domain, found in proteins involved in RNA-mediated gene silencing, and a C-terminal Piwi domain. The encoded protein is thought to function in maintenance of germline cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]