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Several melanomas and renal cell carcinomas along with a few colorectal, breast, endometrial and urothelial cancers showed moderate cytoplasmic and nuclear positivity. Remaining cancers were in general negative.
GENE INFORMATION
Gene name
FAM19A3 (HGNC Symbol)
Synonyms
TAFA-3
Description
Family with sequence similarity 19 (chemokine (C-C motif)-like), member A3 (HGNC Symbol)
Entrez gene summary
This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
