Expression of KCNH7 in cancer - Summary

CANCER ATLAS

Gene description

Potassium channel, voltage gated eag related subfamily H, member 7

Protein class

Predicted membrane proteins, Voltage-gated ion channels

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA018039

GENE INFORMATION
Gene name	KCNH7 (HGNC Symbol)
Synonyms	erg3, HERG3, Kv11.3
Description	Potassium channel, voltage gated eag related subfamily H, member 7 (HGNC Symbol)
Entrez gene summary	Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. There are at least two alternatively spliced transcript variants derived from this gene and encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	q24.2
Chromosome location (bp)	162371407 - 162838730
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000184611 (version 83.38)
Entrez gene	90134
UniProt	Q9NS40 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9NS40
Antibodypedia	KCNH7 antibodies

PROTEIN BROWSER

KCNH7-001	KCNH7-002	KCNH7-201	KCNH7-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCNH7-001 ENSP00000331727 ENST00000332142	Q9NS40 [Direct mapping] Potassium voltage-gated channel subfamily H member 7 Show all	Voltage-gated ion channels Voltage-Gated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005249 [voltage-gated potassium channel activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0007268 [synaptic transmission] GO:0016020 [membrane] GO:0034765 [regulation of ion transmembrane transport] GO:0042391 [regulation of membrane potential] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	1196 aa 135 kDa	No	6
KCNH7-002 ENSP00000333781 ENST00000328032	Q9NS40 [Direct mapping] Potassium voltage-gated channel subfamily H member 7 Show all	Voltage-gated ion channels Voltage-Gated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005249 [voltage-gated potassium channel activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0007268 [synaptic transmission] GO:0016020 [membrane] GO:0034765 [regulation of ion transmembrane transport] GO:0042391 [regulation of membrane potential] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	732 aa 82.9 kDa	No	7
KCNH7-201 ENSP00000482818 ENST00000618399	A0A087WZQ1 [Direct mapping] Potassium voltage-gated channel subfamily H member 7 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005249 [voltage-gated potassium channel activity] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0042391 [regulation of membrane potential] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	1096 aa 123.7 kDa	No	6
KCNH7-202 ENSP00000483158 ENST00000621889	A0A087X077 [Direct mapping] Potassium voltage-gated channel subfamily H member 7 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005249 [voltage-gated potassium channel activity] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0042391 [regulation of membrane potential] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	630 aa 71.3 kDa	No	7