Expression of NELL2 in cancer - Summary

CANCER ATLAS

Gene description

Neural EGFL like 2

Protein class

Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA035715

GENE INFORMATION
Gene name	NELL2 (HGNC Symbol)
Synonyms	NRP2
Description	Neural EGFL like 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a glycoprotein containing several von Willebrand factor C domains and epidermal growth factor (EGF)-like domains. The encoded protein acts as a homotrimer and is found in the cytoplasm. Several variants encoding a few different isoforms exist, and at least one isoform appears to be a secreted protein. Studies in mouse suggest that this protein plays a role in neural cell growth and differentiation as well as in oncogenesis. [provided by RefSeq, Feb 2009]
Chromosome	12
Cytoband	q12
Chromosome location (bp)	44508275 - 44921848
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000184613 (version 83.38)
Entrez gene	4753
UniProt	Q99435 (UniProt - Evidence at protein level)
neXtProt	NX_Q99435
Antibodypedia	NELL2 antibodies

PROTEIN BROWSER

NELL2-001	NELL2-002	NELL2-003	NELL2-005	NELL2-006	NELL2-007	NELL2-009	NELL2-010	NELL2-012	NELL2-013	NELL2-015	NELL2-017	NELL2-019	NELL2-021	NELL2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NELL2-001 ENSP00000416341 ENST00000437801	Q99435 [Direct mapping] Protein kinase C-binding protein NELL2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005080 [protein kinase C binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0008201 [heparin binding] GO:0016020 [membrane] GO:0030425 [dendrite] GO:0040008 [regulation of growth] GO:0042802 [identical protein binding] GO:0043204 [perikaryon] GO:0070050 [neuron cellular homeostasis] GO:0070207 [protein homotrimerization] Show all	866 aa 96.9 kDa	No	1
NELL2-002 ENSP00000390680 ENST00000429094	Q99435 [Direct mapping] Protein kinase C-binding protein NELL2 A0A024R0X1 [Target identity:100%; Query identity:100%] NEL-like 2 (Chicken), isoform CRA_b Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0070050 [neuron cellular homeostasis] Show all	816 aa 91.3 kDa	Yes	0
NELL2-003 ENSP00000447927 ENST00000549027	Q99435 [Direct mapping] Protein kinase C-binding protein NELL2 Show all	SCAMPI predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0070050 [neuron cellular homeostasis] Show all	815 aa 91.2 kDa	Yes	0
NELL2-005 ENSP00000449332 ENST00000551601	F8VVB6 [Direct mapping] Protein kinase C-binding protein NELL2 Show all	SCAMPI predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] Show all	768 aa 85.9 kDa	Yes	0
NELL2-006 ENSP00000327988 ENST00000333837	Q99435 [Direct mapping] Protein kinase C-binding protein NELL2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0070050 [neuron cellular homeostasis] Show all	839 aa 94.2 kDa	No	0
NELL2-007 ENSP00000447085 ENST00000552993	F8W1A2 [Direct mapping] Protein kinase C-binding protein NELL2 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	321 aa 36.4 kDa	Yes	0
NELL2-009 ENSP00000446961 ENST00000551949	F8W1I8 [Direct mapping] Protein kinase C-binding protein NELL2 Show all	Phobius predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		22 aa 2.5 kDa	No	0
NELL2-010 ENSP00000394612 ENST00000452445	Q99435 [Direct mapping] Protein kinase C-binding protein NELL2 A0A024R0X1 [Target identity:100%; Query identity:100%] NEL-like 2 (Chicken), isoform CRA_b Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0070050 [neuron cellular homeostasis] Show all	816 aa 91.3 kDa	Yes	0
NELL2-012 ENSP00000450102 ENST00000550462	H0YIT4 [Direct mapping] Protein kinase C-binding protein NELL2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	122 aa 14.1 kDa	No	0
NELL2-013 ENSP00000448407 ENST00000550313	H0YI34 [Direct mapping] Protein kinase C-binding protein NELL2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] Show all	246 aa 27.8 kDa	No	0
NELL2-015 ENSP00000448107 ENST00000550139	H0YHY5 [Direct mapping] Protein kinase C-binding protein NELL2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] Show all	86 aa 9.2 kDa	No	0
NELL2-017 ENSP00000448635 ENST00000548826	F8VRQ0 [Direct mapping] Protein kinase C-binding protein NELL2 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		112 aa 12.5 kDa	Yes	0
NELL2-019 ENSP00000449068 ENST00000548531	F8VXR5 [Direct mapping] Protein kinase C-binding protein NELL2 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		110 aa 12.2 kDa	Yes	0
NELL2-021 ENSP00000447384 ENST00000553120	F8VZ72 [Direct mapping] Protein kinase C-binding protein NELL2 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		166 aa 18.8 kDa	No	0
NELL2-201 ENSP00000378866 ENST00000395487	Q99435 [Direct mapping] Protein kinase C-binding protein NELL2 Show all	SCAMPI predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0070050 [neuron cellular homeostasis] Show all	815 aa 91.2 kDa	Yes	0