Fields »
ABOUT
HELP
BLOG
AMER1

GENERAL INFORMATION

Gene name

 AMER1

Gene description

 APC membrane recruitment protein 1

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 General nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA065214
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Ovary

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 AMER1 (HGNC Symbol)

Synonyms

 FAM123B, FLJ39827, RP11-403E24.2, WTX

Description

 APC membrane recruitment protein 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene upregulates trancriptional activation by the Wilms tumor protein and interacts with many other proteins, including CTNNB1, APC, AXIN1, and AXIN2. Defects in this gene are a cause of osteopathia striata with cranial sclerosis (OSCS). [provided by RefSeq, May 2010]

Chromosome

 X

Cytoband

 q11.2

Chromosome location (bp)

 64185117 - 64205744

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000184675 (version 83.38)

Entrez gene

 139285

UniProt

 Q5JTC6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q5JTC6

Antibodypedia

 AMER1 antibodies

PROTEIN BROWSER
AMER1-001
AMER1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AMER1-001
ENSP00000364003
ENST00000374869
Q5JTC6 [Direct mapping]
APC membrane recruitment protein 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Frameshift Mutations
Disease related genes
Show all
GO:0005515 [protein binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0008013 [beta-catenin binding]
GO:0016055 [Wnt signaling pathway]
GO:0060828 [regulation of canonical Wnt signaling pathway]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
 804 aa
87.8 kDa 		No 0
AMER1-002
ENSP00000329117
ENST00000330258
Q5JTC6 [Direct mapping]
APC membrane recruitment protein 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Frameshift Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0001822 [kidney development]
GO:0005515 [protein binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0008013 [beta-catenin binding]
GO:0016055 [Wnt signaling pathway]
GO:0060348 [bone development]
GO:0060612 [adipose tissue development]
GO:0060828 [regulation of canonical Wnt signaling pathway]
GO:0072161 [mesenchymal cell differentiation involved in kidney development]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
 1135 aa
124 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.