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HIST2H2BE

CANCER ATLAS

Gene description

 Histone cluster 2, H2be

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA042205
HPA043013
HPA048671

GENE INFORMATION

Gene name

 HIST2H2BE (HGNC Symbol)

Synonyms

 H2B, H2B.1, H2B/q, H2BFQ

Description

 Histone cluster 2, H2be (HGNC Symbol)

Entrez gene summary

 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. The protein has antibacterial and antifungal antimicrobial activity. [provided by RefSeq, Aug 2015]

Chromosome

 1

Cytoband

 q21.2

Chromosome location (bp)

 149842204 - 149886652

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000184678 (version 83.38)

Entrez gene

 8349

UniProt

 Q16778 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16778

Antibodypedia

 HIST2H2BE antibodies

PROTEIN BROWSER
HIST2H2BE-001
HIST2H2BE-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HIST2H2BE-001
ENSP00000358151
ENST00000369155
Q16778 [Direct mapping]
Histone H2B type 2-E
Show all
Predicted intracellular proteins
Show all
GO:0000786 [nucleosome]
GO:0000788 [nuclear nucleosome]
GO:0002227 [innate immune response in mucosa]
GO:0003677 [DNA binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006325 [chromatin organization]
GO:0006334 [nucleosome assembly]
GO:0019731 [antibacterial humoral response]
GO:0046982 [protein heterodimerization activity]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0070062 [extracellular exosome]
Show all
 126 aa
13.9 kDa 		No 0
HIST2H2BE-201
ENSP00000375736
ENST00000369160
Q16778 [Direct mapping]
Histone H2B type 2-E
Show all
Predicted intracellular proteins
Show all
GO:0000786 [nucleosome]
GO:0000788 [nuclear nucleosome]
GO:0002227 [innate immune response in mucosa]
GO:0003677 [DNA binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006325 [chromatin organization]
GO:0006334 [nucleosome assembly]
GO:0019731 [antibacterial humoral response]
GO:0046982 [protein heterodimerization activity]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0070062 [extracellular exosome]
Show all
 126 aa
13.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.