Cell atlas - SEPT5 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SEPT5
Gene description	Septin 5
Protein class	Cancer-related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol & nucleoplasm. In addition localized to the actin filaments.
RNA cell category	Cell line enhanced (K-562)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Cytosol (approved)
Additional location	In addition localized to the Actin filaments (approved)
Mouse	Localized to the Nucleoplasm, Cytosol in mouse cells.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA029095
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ASSAYS

RNA expression

Human cells

Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (K-562) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol & nucleoplasm. In addition localized to the actin filaments.

Main location

Nucleoplasm (approved), Cytosol (approved)

Additional location

Actin filaments (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA029095	PC-3	Nucleoplasm
HPA029095	PC-3	Cytosol
HPA029095	U-2 OS	Nucleoplasm
		Actin filaments
		Cytosol
HPA029095	U-251 MG	Nucleoplasm
HPA029095	U-251 MG	Cytosol

MOUSE CELLS

Main location

Nucleoplasm, Cytosol

Additional location

Actin filaments

Mouse gene

ENSMUSG00000072214 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA029095	NIH 3T3	Nucleoplasm
		Actin filaments
		Cytosol

GENE INFORMATION
Gene name	SEPT5 (HGNC Symbol)
Synonyms	H5, HCDCREL-1, PNUTL1
Description	Septin 5 (HGNC Symbol)
Entrez gene summary	This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced. [provided by RefSeq, Dec 2010]
Chromosome	22
Cytoband	q11.21
Chromosome location (bp)	19714464 - 19724772
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000184702 (version 83.38)
Entrez gene	5413
UniProt	Q99719 (UniProt - Evidence at protein level)
neXtProt	NX_Q99719
Antibodypedia	SEPT5 antibodies

PROTEIN BROWSER

SEPT5-001	SEPT5-002	SEPT5-004	SEPT5-008	SEPT5-009	SEPT5-010	SEPT5-014	SEPT5-016	SEPT5-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SEPT5-001 ENSP00000391311 ENST00000455784	Q99719 [Direct mapping] Septin-5 X5DNA9 [Target identity:100%; Query identity:100%] HCG2002594, isoform CRA_d; Septin 5 isoform A Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000910 [cytokinesis] GO:0003924 [GTPase activity] GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0008021 [synaptic vesicle] GO:0016080 [synaptic vesicle targeting] GO:0017157 [regulation of exocytosis] GO:0019905 [syntaxin binding] GO:0043195 [terminal bouton] GO:0043679 [axon terminus] GO:0045202 [synapse] GO:0045921 [positive regulation of exocytosis] GO:2000300 [regulation of synaptic vesicle exocytosis] Show all	369 aa 42.8 kDa	No	0
SEPT5-002 ENSP00000394541 ENST00000438754	Q99719 [Direct mapping] Septin-5 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000910 [cytokinesis] GO:0003924 [GTPase activity] GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0008021 [synaptic vesicle] GO:0016080 [synaptic vesicle targeting] GO:0017157 [regulation of exocytosis] GO:2000300 [regulation of synaptic vesicle exocytosis] Show all	346 aa 39.3 kDa	No	0
SEPT5-004 ENSP00000372515 ENST00000383045	G3XAH0 [Direct mapping] HCG2002594, isoform CRA_c; Septin-5 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005525 [GTP binding] Show all	378 aa 43.8 kDa	No	0
SEPT5-008 ENSP00000408678 ENST00000412544	C9JM82 [Direct mapping] Septin-5 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005525 [GTP binding] Show all	301 aa 34.7 kDa	No	0
SEPT5-009 ENSP00000378541 ENST00000395109	F8W9E5 [Direct mapping] Septin-5 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005525 [GTP binding] Show all	180 aa 20.6 kDa	No	0
SEPT5-010 ENSP00000414488 ENST00000431124	E7EPG2 [Direct mapping] Septin-5 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005525 [GTP binding] Show all	304 aa 33.8 kDa	No	0
SEPT5-014 ENSP00000384535 ENST00000406395	E7EX32 [Direct mapping] Septin-5 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005525 [GTP binding] Show all	337 aa 38.3 kDa	No	0
SEPT5-016 ENSP00000404673 ENST00000413258	H7C299 [Direct mapping] Septin-5 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005525 [GTP binding] Show all	106 aa 12.5 kDa	No	0
SEPT5-201 ENSP00000480620 ENST00000622227	A0A087WWZ5 [Direct mapping] Septin-5 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005525 [GTP binding] Show all	178 aa 20.2 kDa	No	0