Expression of EIF4ENIF1 in cancer - Summary

CANCER ATLAS

Gene description

Eukaryotic translation initiation factor 4E nuclear import factor 1

Protein class

Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA001619	HPA002078

GENE INFORMATION
Gene name	EIF4ENIF1 (HGNC Symbol)
Synonyms	2610509L04Rik, 4E-T, Clast4, FLJ21601
Description	Eukaryotic translation initiation factor 4E nuclear import factor 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a nucleocytoplasmic shuttle protein for the translation initiation factor eIF4E. This shuttle protein interacts with the importin alpha-beta complex to mediate nuclear import of eIF4E. It is predominantly cytoplasmic; its own nuclear import is regulated by a nuclear localization signal and nuclear export signals. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
Chromosome	22
Cytoband	q12.2
Chromosome location (bp)	31436977 - 31496108
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000184708 (version 83.38)
Entrez gene	56478
UniProt	Q9NRA8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NRA8
Antibodypedia	EIF4ENIF1 antibodies

PROTEIN BROWSER

EIF4ENIF1-001	EIF4ENIF1-002	EIF4ENIF1-003	EIF4ENIF1-005	EIF4ENIF1-006	EIF4ENIF1-008	EIF4ENIF1-009	EIF4ENIF1-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EIF4ENIF1-001 ENSP00000342927 ENST00000344710	Q9NRA8 [Direct mapping] Eukaryotic translation initiation factor 4E transporter Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0008565 [protein transporter activity] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0016605 [PML body] GO:0016607 [nuclear speck] GO:0043231 [intracellular membrane-bounded organelle] GO:0044822 [poly(A) RNA binding] Show all	811 aa 88.2 kDa	No	0
EIF4ENIF1-002 ENSP00000328103 ENST00000330125	Q9NRA8 [Direct mapping] Eukaryotic translation initiation factor 4E transporter A0A024R1K0 [Target identity:100%; Query identity:100%] Eukaryotic translation initiation factor 4E nuclear import factor 1, isoform CRA_a Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0008565 [protein transporter activity] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0016605 [PML body] GO:0016607 [nuclear speck] GO:0043231 [intracellular membrane-bounded organelle] GO:0044822 [poly(A) RNA binding] Show all	985 aa 108.2 kDa	No	0
EIF4ENIF1-003 ENSP00000380659 ENST00000397525	Q9NRA8 [Direct mapping] Eukaryotic translation initiation factor 4E transporter A0A024R1K0 [Target identity:100%; Query identity:100%] Eukaryotic translation initiation factor 4E nuclear import factor 1, isoform CRA_a Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000932 [cytoplasmic mRNA processing body] GO:0003729 [mRNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0008565 [protein transporter activity] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0016605 [PML body] GO:0016607 [nuclear speck] GO:0017148 [negative regulation of translation] GO:0019827 [stem cell population maintenance] GO:0043231 [intracellular membrane-bounded organelle] GO:0044822 [poly(A) RNA binding] GO:0045665 [negative regulation of neuron differentiation] Show all	985 aa 108.2 kDa	No	0
EIF4ENIF1-005 ENSP00000380657 ENST00000397523	B1AKL4 [Direct mapping] Eukaryotic translation initiation factor 4E transporter Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0043231 [intracellular membrane-bounded organelle] Show all	961 aa 105.5 kDa	No	0
EIF4ENIF1-006 ENSP00000405086 ENST00000423097	B1AKL5 [Direct mapping] Eukaryotic translation initiation factor 4E transporter Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		188 aa 21.4 kDa	No	0
EIF4ENIF1-008 ENSP00000380654 ENST00000397520	B1AKL6 [Direct mapping] Eukaryotic translation initiation factor 4E transporter Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		63 aa 7.3 kDa	No	0
EIF4ENIF1-009 ENSP00000380652 ENST00000397518	B1AKL6 [Direct mapping] Eukaryotic translation initiation factor 4E transporter Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		63 aa 7.3 kDa	No	0
EIF4ENIF1-012 ENSP00000413690 ENST00000418321	B0QYZ7 [Direct mapping] Eukaryotic translation initiation factor 4E transporter Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0043231 [intracellular membrane-bounded organelle] Show all	239 aa 26 kDa	No	0