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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse counterpart. This gene is ubiquitously expressed, with high expression seen in adult muscle. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005829 [cytosol] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] GO:0031625 [ubiquitin protein ligase binding] GO:0035458 [cellular response to interferon-beta] GO:0042802 [identical protein binding] GO:0044257 [cellular protein catabolic process] GO:0061630 [ubiquitin protein ligase activity] GO:0061631 [ubiquitin conjugating enzyme activity] GO:0070936 [protein K48-linked ubiquitination] GO:1904153 [negative regulation of retrograde protein transport, ER to cytosol]
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005829 [cytosol] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] GO:0031625 [ubiquitin protein ligase binding] GO:0035458 [cellular response to interferon-beta] GO:0044257 [cellular protein catabolic process] GO:0061630 [ubiquitin protein ligase activity] GO:0061631 [ubiquitin conjugating enzyme activity] GO:0070936 [protein K48-linked ubiquitination] GO:1904153 [negative regulation of retrograde protein transport, ER to cytosol]
