Expression of APOO in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Apolipoprotein O

Protein class

Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA003187

GENE INFORMATION
Gene name	APOO (HGNC Symbol)
Synonyms	FAM121B, MGC4825, Mic23, MIC26, My025
Description	Apolipoprotein O (HGNC Symbol)
Entrez gene summary	This gene is a member of the apolipoprotein family. Members of this protein family are involved in the transport and metabolism of lipids. The encoded protein associates with HDL, LDL and VLDL lipoproteins and is characterized by chondroitin-sulfate glycosylation. This protein may be involved in preventing lipid accumulation in the myocardium in obese and diabetic patients. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 4, 5, 12 and 16.[provided by RefSeq, Sep 2009]
Chromosome	X
Cytoband	p22.11
Chromosome location (bp)	23833353 - 23907934
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000184831 (version 83.38)
Entrez gene	79135
UniProt	Q9BUR5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BUR5
Antibodypedia	APOO antibodies

PROTEIN BROWSER

APOO-001	APOO-002	APOO-005	APOO-006	APOO-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
APOO-001 ENSP00000402557 ENST00000439528	H7C1U8 [Direct mapping] MICOS complex subunit MIC26 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	178 aa 20.1 kDa	No	1
APOO-002 ENSP00000368528 ENST00000379226	Q9BUR5 [Direct mapping] MICOS complex subunit MIC26 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005739 [mitochondrion] GO:0005789 [endoplasmic reticulum membrane] GO:0006869 [lipid transport] GO:0031305 [integral component of mitochondrial inner membrane] GO:0034361 [very-low-density lipoprotein particle] GO:0034362 [low-density lipoprotein particle] GO:0034364 [high-density lipoprotein particle] GO:0042407 [cristae formation] GO:0061617 [MICOS complex] Show all	198 aa 22.3 kDa	Yes	1
APOO-005 ENSP00000488146 ENST00000634086		MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		90 aa 9.9 kDa	No	0
APOO-006 ENSP00000488524 ENST00000633372		Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all		81 aa 9 kDa	No	1
APOO-007 ENSP00000488538 ENST00000633432		SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		49 aa 5.1 kDa	No	0