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Cancer tissues showed weak to moderate cytoplasmic immunoreactivity. Skin cancer along with several gastric and pancreatic cancers were strongly stained. Most lymphomas were negative.
GENE INFORMATION
Gene name
DRD1
Synonyms
Description
Dopamine receptor D1 (HGNC Symbol)
Entrez gene summary
This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. [provided by RefSeq, Jul 2008]