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Most cases of prostate and liver cancers as well as a few cases of melanoma showed moderate immunoreactivity. Remaining cancer tissues were weakly stained or negative.
Most malignant cells displayed moderate cytoplasmic positivity combined with nuclear staining in a few cases. A majority of prostate and thyroid cancers displayed strong immunoreactivity. Several cases of lymphomas and skin cancers were weakly stained.
GENE INFORMATION
Gene name
JAG2
Synonyms
Description
Jagged 2 (HGNC Symbol)
Entrez gene summary
The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]