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MUC6

GENERAL INFORMATION

Gene name

 MUC6

Gene description

 Mucin 6, oligomeric mucus/gel-forming

Protein class

 Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (seminal vesicle, stomach, duodenum)
GTEx:Group enriched (stomach, pancreas)
FANTOM5:Group enriched (seminal vesicle, gallbladder)

Protein evidence

 Evidence at protein level

Protein expression

 Distinct cytoplasmic expression in stomach, seminal vesicle and gallbladder

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
CAB002165
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Stomach

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (seminal vesicle, stomach, duodenum)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (stomach, pancreas)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (seminal vesicle, gallbladder)

GENE INFORMATION

Gene name

 MUC6

Synonyms

Description

 Mucin 6, oligomeric mucus/gel-forming (HGNC Symbol)

Entrez gene summary

 The MUC6 gene encodes gastric mucin, a secreted glycoprotein that plays an essential role in epithelial cytoprotection from acid, proteases, pathogenic microorganisms, and mechanical trauma in the gastrointestinal tract (summary by Toribara et al., 1993 [PubMed 7680650]).[supplied by OMIM, Dec 2010]

Chromosome

 11

Cytoband

 p15.5

Chromosome location (bp)

 1012821 - 1036706

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000184956 (version 83.38)

Entrez gene

 4588

UniProt

 Q6W4X9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6W4X9

Antibodypedia

 MUC6 antibodies

PROTEIN BROWSER
MUC6-001
MUC6-002
MUC6-003
MUC6-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MUC6-001
ENSP00000406861
ENST00000421673
Q6W4X9 [Direct mapping]
Mucin-6
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005201 [extracellular matrix structural constituent]
GO:0005576 [extracellular region]
GO:0005796 [Golgi lumen]
GO:0006493 [protein O-linked glycosylation]
GO:0016266 [O-glycan processing]
GO:0030277 [maintenance of gastrointestinal epithelium]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
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 2439 aa
257 kDa 		Yes 0
MUC6-002
ENSP00000433790
ENST00000525923
E9PJC5 [Direct mapping]
Mucin-6
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0030277 [maintenance of gastrointestinal epithelium]
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 181 aa
19.3 kDa 		No 0
MUC6-003
ENSP00000436903
ENST00000527242
H0YEZ6 [Direct mapping]
Mucin-6
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 115 aa
11.4 kDa 		No 0
MUC6-004
ENSP00000433246
ENST00000532016
H0YDA7 [Direct mapping]
Mucin-6
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 219 aa
22.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.