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CHRM5

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GENERAL INFORMATION

Gene name

 CHRM5

Gene description

 Cholinergic receptor, muscarinic 5

Protein class

 FDA approved drug targets
G-protein coupled receptors
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Group enriched (HMC-1, BEWO)

Protein evidence

 Evidence at transcript level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (HMC-1, BEWO)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 CHRM5

Synonyms

Description

 Cholinergic receptor, muscarinic 5 (HGNC Symbol)

Entrez gene summary

 The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, stimulation of this receptor is known to increase cyclic AMP levels. [provided by RefSeq, Jul 2008]

Chromosome

 15

Cytoband

 q14

Chromosome location (bp)

 33968720 - 34067457

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000184984 (version 83.38)

Entrez gene

 1133

UniProt

 P08912 (UniProt - Evidence at transcript level)

neXtProt

 NX_P08912

Antibodypedia

 CHRM5 antibodies

PROTEIN BROWSER
CHRM5-001
CHRM5-002
CHRM5-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CHRM5-001
ENSP00000372750
ENST00000383263
P08912 [Direct mapping]
Muscarinic acetylcholine receptor M5
A0A024R9I2 [Target identity:100%; Query identity:100%]
Muscarinic acetylcholine receptor
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001696 [gastric acid secretion]
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007197 [adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway]
GO:0007207 [phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway]
GO:0007213 [G-protein coupled acetylcholine receptor signaling pathway]
GO:0007271 [synaptic transmission, cholinergic]
GO:0007606 [sensory perception of chemical stimulus]
GO:0008283 [cell proliferation]
GO:0015872 [dopamine transport]
GO:0016021 [integral component of membrane]
GO:0016907 [G-protein coupled acetylcholine receptor activity]
GO:0019226 [transmission of nerve impulse]
GO:0030054 [cell junction]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0060304 [regulation of phosphatidylinositol dephosphorylation]
Show all
 532 aa
60.1 kDa 		No 7
CHRM5-002
ENSP00000453745
ENST00000557872
P08912 [Direct mapping]
Muscarinic acetylcholine receptor M5
A0A024R9I2 [Target identity:100%; Query identity:100%]
Muscarinic acetylcholine receptor
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001696 [gastric acid secretion]
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007197 [adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway]
GO:0007207 [phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway]
GO:0007213 [G-protein coupled acetylcholine receptor signaling pathway]
GO:0007271 [synaptic transmission, cholinergic]
GO:0007606 [sensory perception of chemical stimulus]
GO:0008283 [cell proliferation]
GO:0016021 [integral component of membrane]
GO:0030054 [cell junction]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
Show all
 532 aa
60.1 kDa 		No 7
CHRM5-003
ENSP00000452742
ENST00000560035
H0YKC0 [Direct mapping]
Muscarinic acetylcholine receptor M5
Show all
Predicted intracellular proteins
Show all
GO:0007207 [phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway]
GO:0007271 [synaptic transmission, cholinergic]
GO:0007606 [sensory perception of chemical stimulus]
GO:0045202 [synapse]
Show all
 22 aa
2.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.